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Mini-Reviews in Organic Chemistry

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ISSN (Online): 1875-6298

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Mini-Review Article

1-Cyanoacetylthiosemicarbazides: Recent Advances in their Synthesis, Reactivity in Heterocyclization, and Bio-Applications

Author(s): Samir Bondock*, Nada Alabbad, Aisha Hossan and Moaz M. Abdou

Volume 21, Issue 4, 2024

Published on: 07 July, 2023

Page: [409 - 423] Pages: 15

DOI: 10.2174/1570193X20666230529155754

Price: $65

Abstract

The synthesis of 1-cyanoacetylthiosemicarbazides is at the apex attention of researchers due to their multifaced reactivity as versatile precursors in the synthesis of mono-, bi-, and fused_heterocyclic compounds as well as metal complexes. Despite this, no comprehensive survey was, so far, dedicated to the synthesis, chemical transformation, and bioactivities of this relevant family of synthetic organic precursors and their derivatives. The present survey aims to summarize an up-to-date record of the preparation of 1-cyanoacetylthiosemicarbazides and their chemical transformation. A particular focus is given to their metal complexes and bio-applications

Keywords: Cyanoacetylthiosemicarbazide, pyrazoles, 1 , 3, 4-oxadiazoles, 1 , 3 , 4-thiadiazoles, 1, 2, 4-triazoles, pyridines, fusedhetarenes, bio-applications.

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