Hepatitis E infection is an important problem in developing countries. Hepatitis E vaccination is important for prevention but it influenced by the resident’s knowledge. The Qingdao residents’ knowledge of hepatitis E is still unknown. This study used online survey on the Wechat platform for investigation. Chi-square test was used to compare the hepatitis E influencing factors between subgroups. Binary logistic regression was used for multiple factor analysis to explore the hepatitis E influencing factors. We have found the total awareness rate of hepatitis E was 60.51%. Females, aged between 51 and 60, aged 61 and above, worked in government-affiliated departments were found to have higher awareness rate than other subgroups. The participants who have family members infected with hepatitis E were found to have lower awareness rate. The government and relevant departments should focus on the education of the hepatitis E vaccination and the disease process.