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Is lysosomal acid lipase activity associated with the presence and severity of coronary artery disease?

Steht die Aktivität der lysosomalen sauren Lipase in Zusammenhang mit dem Vorliegen und dem Schweregrad einer koronaren Herzkrankheit?

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Abstract

Background

Lipid metabolism is considerably complex and there can be many critical steps in atherogenesis. The association between lysosomal acid lipase (LAL) activity and coronary artery disease (CAD) has not been elucidated in detail. We aimed to evaluate the association between LAL activity with the presence and severity of CAD in patients who are seen in daily clinical practice.

Methods

Patients who underwent coronary angiography were divided into groups according to the angiography results. Syntax scores and Gensini scores were calculated. The LAL activity was measured from dried blood spots.

Results

Median LAL activity values were similar in all study groups (normal coronary arteries: 0.40 nmol/punch/h; non-obstructive CAD: 0.44 nmol/punch/h; obstructive chronic CAD: 0.40 nmol/punch/h; obstructive acute coronary syndrome: 0.48 nmol/punch/h) and there was no correlation between coronary atherosclerotic burden and LAL activity (correlation coefficients Syntax score and LAL: −0.032; Gensini score and LAL: −0.030). In addition, no relationship between serum lipid levels and LAL activity was detected.

Conclusion

The presence of CAD and its severity is not associated with the LAL activity in patients encountered in daily clinical practice.

Zusammenfassung

Hintergrund

Der Lipidmetabolismus ist sehr komplex, und es können viele kritische Schritte bei der Atherogenese auftreten. Der Zusammenhang zwischen der Aktivität der lysosomalen sauren Lipase (LAL) und einer koronaren Herzkrankheit (KHK) ist bisher noch nicht genau untersucht worden. Ziel der Arbeit war es, den Zusammenhang zwischen der LAL-Aktivität und dem Vorliegen sowie dem Schweregrad einer KHK bei Patienten zu untersuchen, die sich in der täglichen klinischen Praxis vorstellen.

Methoden

Auf Basis der Ergebnisse in der Angiographie wurden Patienten, bei denen eine Koronarangiographie durchgeführt wurde, in Gruppen aufgeteilt. Der SYNTAX-Score und der Gensini-Score wurden ermittelt. Die LAL-Aktivität wurden anhand von getrockneten Blutstropfen gemessen.

Ergebnissse

Die mittleren Werte für die LAL-Aktivität waren in allen Studiengruppen ähnlich (normale Koronararterien: 0,40 nmol/Stanze/h; nichtobstruktive KHK: 0,44 nmol/Stanze/h; obstruktive chronische KHK: 0,40 nmol/Stanze/h; obstruktives akutes Koronarsyndrom: 0,48 nmol/Stanze/h), und es bestand keine Korrelation zwischen der durch Koronaratherosklerose bedingten Krankheitslast und der LAL-Aktivität (Korrelationskoeffizient für SYNTAX-Score und LAL: −0,032; für Gensini-Score und LAL: −0,030). Außerdem wurde kein Zusammenhang zwischen den Serumlipidspiegeln und der LAL-Aktivität festgestellt.

Schlussfolgerung

Das Vorliegen einer KHK und deren Schweregrad stehen bei Patienten, die sich in der täglichen klinischen Praxis vorstellen, nicht mit der LAL-Aktivität in Zusammenhang.

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Acknowledgements

The authors appreciate the Gazi University Scientific Research Projects Department for their financial support.

Funding

The study was supported by the Gazi University Scientific Research Projects Department (Project number 5951).

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Authors and Affiliations

  1. Department of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey

    Emrullah Kızıltunç MD, Associate Professor of Cardiology, Yakup Yalçın MD, Burcu Cihan MD, Mehmet R Yalçın MD, Professor of Cardiology & Adnan Abacı MD, Professor of Cardiology

  2. Department of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey

    Sabire Gökalp MD, Gürsel Biberoğlu MD, Professor of Pediatric Metabolism and Nutrition, Rıdvan M Öktem MD, Assistant Professor of Pediatric Metabolism and Nutrition, Aslı İnci MD, Associate Professor of Pediatric Metabolism and Nutrition & Leyla Tümer MD, Professor of Pediatric Metabolism and Nutrition

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  1. Emrullah Kızıltunç MD, Associate Professor of Cardiology
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  2. Sabire Gökalp MD
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  3. Gürsel Biberoğlu MD, Professor of Pediatric Metabolism and Nutrition
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  4. Yakup Yalçın MD
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  6. Rıdvan M Öktem MD, Assistant Professor of Pediatric Metabolism and Nutrition
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  7. Aslı İnci MD, Associate Professor of Pediatric Metabolism and Nutrition
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  8. Leyla Tümer MD, Professor of Pediatric Metabolism and Nutrition
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  9. Mehmet R Yalçın MD, Professor of Cardiology
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  10. Adnan Abacı MD, Professor of Cardiology
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Corresponding author

Correspondence to Emrullah Kızıltunç MD, Associate Professor of Cardiology.

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Conflict of interest

E. Kızıltunç, S. Gökalp, G. BiberoğluX, Y. Yalçın, B. Cihan, R.M. Öktem, A. İnci, L. Tümer, M.R. Yalçın and A. Abacı declare that they have no competing interests.

The study protocol was approved by the local ethicsal committee. Written informed consent was obtained from all patients. The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki. The study was supported by the Gazi University Scientific Research Projects Department (Project number 5951).

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The corresponding author will share the study data upon reasonable request

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Kızıltunç, E., Gökalp, S., Biberoğlu, G. et al. Is lysosomal acid lipase activity associated with the presence and severity of coronary artery disease?. Herz 49, 75–80 (2024). https://doi.org/10.1007/s00059-023-05200-7

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  • DOI: https://doi.org/10.1007/s00059-023-05200-7

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