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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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Review Article

The Emerging Roles of circRNAs in Papillary Thyroid Carcinoma: Molecular Mechanisms and Biomarker Potential

Author(s): Haihan Ye, Xiaoyang Sun, Qianyun Ding, Enyu Yang, Shuo Zhao, Xiaowei Fan, Meiyu Fang and Xianfeng Ding*

Volume 30, Issue 9, 2023

Published on: 29 August, 2023

Page: [709 - 718] Pages: 10

DOI: 10.2174/0929866530666230804104057

Price: $65

Abstract

Papillary thyroid carcinoma (PTC) is a common endocrine malignant tumor. The incidence of PTC has increased in the past decades and presents a younger trend. Accumulating evidence indicates that circular RNAs (circRNAs), featured with non-linear, closed-loop structures, play pivotal roles in tumorigenesis and regulate cell biological processes, such as proliferation, migration, and invasion, by acting as microRNA (miRNA) sponges. Additionally, due to their unique stability, circRNAs hold promising potential as diagnostic biomarkers and effective therapeutic targets for PTC treatment. In this review, we systematically arrange the expression level of circRNAs, related clinical characteristics, circRNA-miRNA-mRNA regulatory network, and molecular mechanisms. Furthermore, related signaling pathways and their potential ability of diagnostic biomarkers and therapeutic targets are discussed, which might provide a new strategy for PTC diagnosis, monitoring, and prognosis.

Keywords: Biomarker, circRNA, molecular mechanism, papillary thyroid carcinoma, sponges, miRNA.

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