Skip to main content
SpringerLink
Log in

Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus

  • Research Letter
  • Published:
World Journal of Pediatrics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Data availability statement

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. Ashour A, Faisal M, Ibrahim E, Al-Madani M. Splenic infarcts in a lady with systemic lupus erythematosus and negative antiphospholipid antibodies—a rare case report. Clin Case Rep. 2023;11:e7092.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Antopolsky M, Hiller N, Salameh S, Goldshtein B, Stalnikowicz R. Splenic infarction: 10 years of experience. Am J Emerg Med. 2009;27:262–5.

    Article  PubMed  Google Scholar 

  3. Fishman D, Isenberg DA. Splenic involvement in rheumatic diseases. Semin Arthritis Rheum. 1997;27:141–55.

    Article  CAS  PubMed  Google Scholar 

  4. Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME. Clinical disease activity and flare in SLE: current concepts and novel biomarkers. J Autoimmun. 2021;119:102615.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kaul A, Gordon C, Crow MK, Touma Z, Urowitz MB, van Vollenhoven R, et al. Systemic lupus erythematosus. Nat Rev Dis Primers. 2016;2:16039.

    Article  PubMed  Google Scholar 

  6. Dillon AM, Stein HB, Kassen BO, Ibbott JW. Hyposplenia in a patient with systemic lupus erythematosus. J Rheumatol. 1980;7:196–8.

    CAS  PubMed  Google Scholar 

  7. Constantin T, Ponyi A, Varga E, Dankó K, Fekete G, Kovács G. Antiphospholipid syndrome accompanied by a silent splenic infarct in a patient with juvenile SLE. Rheumatol Int. 2006;26:951–2.

    Article  PubMed  Google Scholar 

  8. Senken B, Whitehead A. Catastrophic antiphospholipid syndrome presenting as a stroke in an 11-year-old with lupus. Case Rep Pediatr. 2022;2022:7890566.

    PubMed  PubMed Central  Google Scholar 

  9. Hirakawa E, Saito K, Hirata S, Atsumi T, Koike T, Tanaka Y. A case of catastrophic antiphospholipid antibody syndrome complicated with systemic lupus erythematosus, double positive for anti-cardiolipin/β2 glycoprotein I and anti-phosphatidylserine/ prothrombin autoantibodies. Mod Rheumatol. 2012;22:769–73.

    Article  PubMed  Google Scholar 

  10. Chen LC, Huang JL. CT of splenic infarction in SLE. Pediatr Radiol. 1998;28:721.

    Article  CAS  PubMed  Google Scholar 

  11. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. 2019 European league against rheumatism/american college of rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019;78:1151–9.

    Article  PubMed  Google Scholar 

  12. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295–306.

    Article  CAS  PubMed  Google Scholar 

  13. Balcar I, Seltzer SE, Davis S, Geller S. CT patterns of splenic infarction: a clinical and experimental study. Radiology. 1984;151:723–9.

    Article  CAS  PubMed  Google Scholar 

  14. Itoh K, Hayashi A, Kawai T, Sumiya M, Kano S. Echography of splenic infarct in a case of systemic lupus erythematosus. J Clin Ultrasound. 1978;6:113–4.

    Article  CAS  PubMed  Google Scholar 

  15. Asherson RA, Morgan SH, Harris EN, Gharavi AE, Krausz T, Hughes GR. Arterial occlusion causing large bowel infarction—a reflection of clotting diathesis in SLE. Clin Rheumatol. 1986;5:102–6.

    Article  CAS  PubMed  Google Scholar 

  16. Allali D, Puppa G, Lupus CCJ. Mesenteric inflammatory veno-occlusive disease of the spleen metasynchronous with two arterial thrombotic events in systemic lupus erythematosus. Lupus. 2018;27:150–3.

    Article  CAS  PubMed  Google Scholar 

  17. Rzepecki AK, Park M, Amin B, Dunec A, McLellan BN, Balagula Y. A unique clinical and histologic presentation of catastrophic systemic calciphylaxis in a nonuremic patient with systemic lupus erythematosus. JAAD Case Rep. 2019;5:245–8.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Robinett KS, McCurdy M, Verceles AC. An unusual case of thrombocytopenia, altered mental status with renal and splenic infarctions in a 25-year old patient with systemic lupus erythematosus. Am J Respir and Crit Care Med. 2010;181:A4597.

    Google Scholar 

  19. Sheth K, Snyder A, Wu U, Lahiri B, Grover P. Catastrophic pneumococcal meningitis in a patient with autosplenectomy from lupus/antiphospholipid antibody syndrome. J Gen Intern Med. 2015;30:S312–3.

    Google Scholar 

  20. Ogriki T, Fomberstein B. A fatal case of heparin-induced thrombocytopenia coexisting with secondary antiphospholipid syndrome. J Gen Intern Med. 2017;32:S408.

    Google Scholar 

  21. Soy M, Sayin NC. Rheumatology EUJC. Splenic infarction in a pregnant woman with systemic lupus erythematosus. Clin Rheumatol. 2005;24:663–4.

    Article  PubMed  Google Scholar 

  22. Dhillon PK, Adams MJ. Thrombosis in systemic lupus erythematosus: role of impaired fibrinolysis. Semin Thromb Hemost. 2013;39:434–40.

    Article  CAS  PubMed  Google Scholar 

  23. Weber E, Grangeon F, Reynaud Q, Hot A, Seve P, Jardel S, et al. Acute renal and splenic infarctions: a review. QJM. 2020;113:186–93.

    CAS  PubMed  Google Scholar 

  24. Kara E, Ayden H. Antiphospholipid antibody syndrome (APS) presenting as splenic thrombosis and acute acalculous cholecystitis. Acta Chir Belg. 2004;104:733–5.

    Article  CAS  PubMed  Google Scholar 

  25. Arnold MH, Schrieber L. Splenic and renal infarction in systemic lupus erythematosus: association with anti-cardiolipin antibodies. Clin Rheumatol. 1988;7:406–10.

    Article  CAS  PubMed  Google Scholar 

  26. Tazi Mezalek Z, Maamar M, Harmouche H, Bachir H, Ammouri W, Adnaoui M. Systemic lupus erythematosus in a patient with sickle cell disease. Lupus. 2014;23:499.

    Google Scholar 

  27. Goerg C, Schwerk WB. Splenic infarction: sonographic patterns, diagnosis, follow-up, and complications. Radiology. 1990;174:803–7.

    Article  CAS  PubMed  Google Scholar 

  28. Maresca G, Mirk P, De Gaetano A, Barbaro B, Colagrande C. Sonographic patterns in splenic infarct. J Clin Ultrasound. 1986;14:23–8.

    Article  CAS  PubMed  Google Scholar 

  29. Yeh HC, Zacks J, Jurado RA. Ultrasonography of splenic infarct. Mt Sinai J Med. 1981;48:446–8.

    CAS  PubMed  Google Scholar 

  30. Wand O, Tayer-Shifman OE, Khoury S, Medicine AYHJAo. A practical approach to infarction of the spleen as a rare manifestation of multiple common diseases. Ann Med. 2018;50:494–500.

    Article  CAS  PubMed  Google Scholar 

  31. Robertson F, Leander P, Ekberg O. Radiology of the spleen Eur radiol. 2001;11:80–95.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank the patients and their families for participating in this study. They also thank the doctors, nurses, and other health care providers.

Funding

This work was supported partly by the National Key R&D Program of China (Grant Number 2021YFC2702005) and Beijing Hospitals Authority’s Ascent Plan (DFL20221001).

Author information

Authors and Affiliations

  1. Department of Immunology, Ministry of Education Key Laboratory of Major Diseases in Children, Beijing Key Laboratory for Genetics of Birth Defects, National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, No. 56 Nan Li Shi Lu, Beijing, 100045, China

    Yan Li, Yu-Rong Piao, Tong-Xin Han & Hua-Wei Mao

Authors
  1. Yan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu-Rong Piao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tong-Xin Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hua-Wei Mao
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MHW contributed to conceptualization and writing––review and editing. HTX and PYY performed data curation. LY wrote the original draft. All the authors contributed to the article and approved the submitted version.

Corresponding author

Correspondence to Hua-Wei Mao.

Ethics declarations

Conflict of interest

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

Ethical approval

This study was conducted in accordance with the tenets of the Declaration of Helsinki and was approved by the ethics committee of Beijing Children’s Hospital (IEC clearance number: [2022]-E-065-R).

Informed consent

Informed consent to participate in this study has been obtained from parents or legal guardians of all patients. Written consent for publication of the cases’ details together with imaging has been obtained from parent or legal guardians.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, Y., Piao, YR., Han, TX. et al. Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus. World J Pediatr (2023). https://doi.org/10.1007/s12519-023-00748-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12519-023-00748-0

Search

Navigation