Abstract
As a novel and environmentally friendly Brönsted acid, imidazole hydrochloride was used to promote the synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives. The essence of this reaction is a multicomponent reaction, which constructs multiple chemical bonds between different components through the transamidation of imidazole hydrochloride. This protocol showed a wide range of functional group tolerance, and a series of quinazolinones were synthesized in low to moderate yields without metal cata-lysts, oxidants or other additives.
Keywords: multicomponent reaction, 3-disubstituted-4(3H)-quinazolinone, DMF derivatives, Imidazole hydrochloride, 2, Brönsted acid, imidazole hydrochloride