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Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland

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Abstract

The pituitary gland is a major endocrine tissue composing of two distinct entities, the adenohypophysis (anterior pituitary, cranial placode origin) and the neurohypophysis (posterior pituitary, neural ectoderm origin), and plays important roles in maintaining vital homeostasis. This tissue is maintained by a slow, consistent cell-renewal system of adult stem/progenitor cells. Recent accumulating evidence shows that neural crest-, head mesenchyme-, and endoderm lineage cells invade during pituitary development and contribute to the maintenance of the adult pituitary gland. Based on these novel observations, this article discusses whether these lineage cells are involved in pituitary organogenesis, maintenance, regeneration, dysplasia, or tumors.

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Acknowledgements

The authors would like to express our deep gratitude to everyone who belonged to the Laboratory of Molecular Biology and Gene Regulation, Department of Life Sciences, School of Agriculture, Meiji University, and to Ms. Kyoko Tomizawa and many collaborators of other research institutions for the research results that provide the background of this paper. We would like to thank Editage (www.editage.com) for English language editing.

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  1. Institute for Endocrinology, Meiji University, 1-1-1 Higashi-Mita, Tama-Ku, Kawasaki, Kanagawa, 214-8571, Japan

    Yukio Kato & Takako Kato

  2. Department of Biochemistry, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan

    Saishu Yoshida

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  1. Yukio Kato
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Kato, Y., Yoshida, S. & Kato, T. Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland. Cell Tissue Res 394, 487–496 (2023). https://doi.org/10.1007/s00441-023-03829-8

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