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Effect of Liquid Paraffin on the Characteristics of Pressure-Sensitive Adhesives Applied to Medical Tape Formulations

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Abstract

Purpose

Styrene–isoprene–styrene (SIS) block copolymer-based pressure-sensitive adhesives (PSAs) are used in many applications with various additives. These PSAs can provide proper adhesion and high cohesive strength in tape formulations. Potential advantages of increasing the content of LP are that the PSAs become more flexible, resulting in easier deforming along the body surface shape, which improves adhesion to the skin surface. However, it is important to maintain an appropriate balance between SIS copolymer and LP because an excessive amount of LP may reduce the adhesiveness and cohesive strength of the PSAs. Here we investigated the effect of varying percentages of liquid paraffin (LP) on SIS copolymer-based PSA formulations with the proportion of alicyclic saturated hydrocarbon resin fixed at 30%.

Methods

These formulations were assessed for their adhesion and peeling characteristics by measuring their viscoelasticity in the linear range and using peel adhesion and texture analysis tests. In addition, we evaluated the intermolecular interactions in these PSAs using differential scanning calorimetry and Fourier transform infrared spectroscopy.

Results

As the LP/SIS ratio exceeded 2.5, the adhesion performance of PSA declined. However, the 180° peel adhesion test and texture analysis revealed that peel adhesion decreased nonlinearly with increasing LP/SIS copolymer ratio. The adhesion distance remained unchanged, and no cohesive breakdown of the probe was observed when the LP/SIS copolymer ratio exceeded 2.5.

Conclusion

These results provide valuable information for regulating adhesion and peel characteristics of tape formulations by varying their LP/SIS copolymer ratio as the amount of adhesive agent remains fixed.

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Data Availability

The datasets generated and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.

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Funding

This study was funded by Dojin Iyaku-Kako Co., Ltd.

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Authors and Affiliations

  1. Department of Pharmaceutical Engineering and Drug Delivery Science, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka, 422-8526, Japan

    Takayuki Terukina, Saori Muramoto, Kaede Osanai, Miho Inoue & Hiromu Kondo

  2. Department of Research, Division of Research & Development, Dojin Iyaku-Kako Co., Ltd, 8-1, Higashi Nakakawara, Senoue-machi, Fukushima-shi, Fukushima, 960-0101, Japan

    Hirotaka Watanabe, Yuki Hakamata & Haruhiko Hikichi

Authors
  1. Takayuki Terukina
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  2. Saori Muramoto
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  3. Kaede Osanai
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  4. Miho Inoue
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  5. Hirotaka Watanabe
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  7. Haruhiko Hikichi
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  8. Hiromu Kondo
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Contributions

T. Terukina, S. Muramoto, K. Osanai, M. Inoue, H. Watanabe, Y. Hakamata, H. Hikichi, and H. Kondo were involved in the study design and data interpretation. T. Terukina, S. Muramoto, K. Osanai, and M. Inoue were involved in the data analysis. All authors critically revised the report, commented on drafts of the manuscript, and approved the final report.

Corresponding author

Correspondence to Hiromu Kondo.

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Conflict of Interest

H. Kondo and T. Terukina received a research grant from Dojin Iyaku-Kako Co., Ltd.; H. Watanabe, Y. Hakamata, and H. Hikichi are employees of Dojin Iyaku-Kako Co., Ltd.

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Summary: This study investigated the effect of different percentages of liquid paraffin (LP) on characteristics of styrene–isoprene–styrene (SIS) block copolymer-based pressure-sensitive adhesives in tape formulations. Adhesion and cohesiveness were assessed through viscoelasticity, peel adhesion tests, and texture analysis. Results showed that the adhesion performance decreased when the LP/SIS copolymer ratio increased. The viscoelasticity test suggested that the cohesive strength decreased as the LP ratio in the PSA increased. The study provides valuable insights into regulating adhesion, peel characteristics, and cohesiveness in tape formulations by adjusting the LP/SIS copolymer ratio while keeping the tackifier amount constant.

Teaser: Effect of liquid paraffin (LP) on styrene–isoprene–styrene (SIS) block copolymer-based tape formulations: LP/SIS ratio affected adhesion performance, providing valuable information to design tape formulations.

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Terukina, T., Muramoto, S., Osanai, K. et al. Effect of Liquid Paraffin on the Characteristics of Pressure-Sensitive Adhesives Applied to Medical Tape Formulations. J Pharm Innov 18, 2110–2119 (2023). https://doi.org/10.1007/s12247-023-09777-8

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