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Euchronin A–F isolated from the Arnebia euchroma (Royle) Johnst. and their anti-proliferative activities in vitro

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Abstract

Six new naphthoquinones, euchronin A–F (1–6) and nine known naphthoquinones (7–15), were isolated from the roots of Arnebia euchroma (Royle) Johnst. The structures of the new compounds were confirmed by extensive spectroscopic analyses, including UV, IR, HR-ESI–MS, 1D and 2D NMR. In the present study, we estimated the anti-proliferative activities of these compounds with HaCaT cells. The results indicated that compounds 2 and 4 showed strong anti-proliferative activities at 25 μM, with relative viability at 38.83% and 68.44%, respectively.

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Acknowledgements

Thanks for the support of the Key Research and Development Projects of Heilongjiang Province (GA21D008) and Heilongjiang Touyan Innovation Team Program.

Funding

This work was financially supported by the Key Research and Development Projects of Heilongjiang Province (GA21D008), Heilongjiang Touyan Innovation Team Program.

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Authors and Affiliations

  1. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040, People’s Republic of China

    Zhen-Peng Zhang, Yan Liu, Hai-Dan Zou, Juan Pan, Zhi-Chao Hao, Wei Guan, Adnan Mohammed Algradi, Hai-Xue Kuang & Bing-You Yang

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  1. Zhen-Peng Zhang
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  2. Yan Liu
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  3. Hai-Dan Zou
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Contributions

Z-PZ: writing original draft. YL: validation and investigation. H-DZ: identification of compounds. JP: NMR test. Z-CH: cell test. WG: HR-ESI–MS test. AMA: check grammar and spelling errors. H-XK: corresponding author. B-YY: corresponding author.

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Correspondence to Hai-Xue Kuang or Bing-You Yang.

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Zhang, ZP., Liu, Y., Zou, HD. et al. Euchronin A–F isolated from the Arnebia euchroma (Royle) Johnst. and their anti-proliferative activities in vitro. J Nat Med 78, 33–41 (2024). https://doi.org/10.1007/s11418-023-01738-2

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  • DOI: https://doi.org/10.1007/s11418-023-01738-2

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