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Nitro-Substituted Pyridinimine Complexes of Pd(II): Synthesis and Inhibition of MAO-B ex vivo

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Abstract

The first ever synthesis of complexes [PdLCl2] (I) and [PdLBr2] (II) was successfully achieved, where L = 2,6-dimethyl-4-nitro-N-(pyridin-2-ylmethylildene)aniline, a ligand with a purported ability to inhibit monoamine oxidase B (MAO-B). To gain insight into the molecular structure of complexes I and II, as well as the ligand precursor 2,6-dimethyl-4-nitroaniline L4 (CIF files CCDC nos. 2255106 (I), 2255105 (II), 2255103 (L), 2255104 (L4)), X-ray diffraction analysis was utilized. Complex I underwent further characterization to determine its stability, solubility, and lipophilicity. Cytotoxicity studies of substances L, I, and II on human embryonic kidney cell line HEK-293 showed no evidence of cytotoxic activity. To evaluate the inhibitory activity of new substances L, I, and II as well as established substances III−IX, selegiline, and rasagiline, ex vivo studies were conducted, establishing a structure/activity relationship.

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ACKNOWLEDGMENTS

The work was carried out using the equipment of The Core Facilities Centre “Research of materials and matter” at the PFRC UB RAS. The author acknowledges O.A. Maiorova (Perm Federal Research Center, Ural Branch, RAS) for recording the NMR spectra, I.A. Borisova (Perm Federal Research Center, Ural Branch, RAS) for recording the IR spectra, M.V. Dmitriev for X-ray (Perm State University), A.A. Gorbunov for GC-MS and A.O. Voronina and O.N. Gagarskikh (Perm Federal Research Center, Ural Branch, RAS) for performing the MTT test.

Funding

The study was supported by the Russian Foundation for Basic Research and the Perm Region Ministry of Education and Science according to the Research Project no. 19-43-590003.

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  1. Institute of Technical Chemistry of Ural Branch of the RAS, Perm, Russia

    M. S. Denisov & Yu. A. Beloglazova

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Denisov, M.S., Beloglazova, Y.A. Nitro-Substituted Pyridinimine Complexes of Pd(II): Synthesis and Inhibition of MAO-B ex vivo. Russ J Coord Chem 49, 565–576 (2023). https://doi.org/10.1134/S1070328423600626

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