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Impact of zolpidem and lemborexant on sleep and morning symptoms when used as a single dose for polysomnography

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Abstract

This study evaluated the effect of zolpidem and lemborexant on sleep and morning symptoms in patients undergoing type-1 polysomnography for suspected sleep-disordered breathing based on questionnaires and polysomnography results. We enrolled 127 patients (lemborexant: N = 57, zolpidem: N = 25, without hypnotics: N = 45). Rapid eye movement sleep in patients on lemborexant was higher than that in patients without hypnotics (P = 0.02). Frequency of unsteadiness in the morning was higher in patients on zolpidem than that in patients without hypnotics (P = 0.04), which remained after adjustment for potential confounders (P = 0.03). Low-dose lemborexant might be suitable when administered as a single dose during polysomnography.

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Authors and Affiliations

  1. Department of Perioperative and Critical Care Management, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    Hiroyuki Sawatari

  2. Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Tomoko Yoshikawa

  3. Sleep Medicine Center, Saiseikai Futsukaichi Hospital, 3-13-1 Yumachi, Chikushino, Fukuoka, 818-8516, Japan

    Shin-ichi Ando

Authors
  1. Hiroyuki Sawatari
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  2. Tomoko Yoshikawa
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  3. Shin-ichi Ando
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Correspondence to Shin-ichi Ando.

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Sawatari, H., Yoshikawa, T. & Ando, Si. Impact of zolpidem and lemborexant on sleep and morning symptoms when used as a single dose for polysomnography. Sleep Biol. Rhythms 22, 155–158 (2024). https://doi.org/10.1007/s41105-023-00485-x

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  • DOI: https://doi.org/10.1007/s41105-023-00485-x

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