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Post-dynamic, isometric and combined resistance exercise responses in medicated hypertensive men

Journal of Human Hypertension volume 38, pages 52–61 (2024)Cite this article

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Abstract

This study investigated the effects of dynamic resistance exercise (DRE), isometric handgrip exercise (IHE) and combined resistance exercise (DRE+IHE) on post-exercise hypotension (PEH) and its hemodynamic, autonomic, and vascular mechanisms. For that, 70 medicated hypertensives men (52 ± 8 years) were randomly allocated to perform one of the following interventions: DRE (3 sets, 8 exercises, 50% of 1RM), IHE (4 sets, 2 min, 30% of MVC), CRE (DRE+IHE) and control (CON, seated rest). Before and after the interventions, blood pressure (BP), systemic hemodynamics, cardiovascular autonomic modulation and brachial vascular parameters were evaluated. After the DRE and CRE, systolic and mean BP decreased (SBP = −7 ± 6 and −8 ± 8 mmHg; MBP −4 ± 5 and −5 ± 5 mmHg, respectively, all P < 0.05), vascular conductance increased (+ 0.47 ± 0.61 and +0.40 ± 0.47 ml.min−1.mmHg−1, respectively, both P < 0.05) and baroreflex sensitivity decreased (−0.15 ± 0.38 and −0.29 ± 0.47 ms/mmHg, respectively, both P < 0.05) in comparison to pre-exercise values. No variable presented any significant change after IHE. The responses observed after CRE were similar to DRE and significantly different from CON and IHE. In conclusion, DRE, but not IHE, elicits PEH, which happens concomitantly to skeletal muscle vasodilation and decreased baroreflex sensitivity. Moreover, adding IHE to DRE does not potentiate PEH and neither changes its mechanisms.

Clinical Trial Registration: Data from this study derived from an ongoing longitudinal clinical trial approved by the Institution’s Ethics Committee of Human Research (process 2.870.688) and registered at the Brazilian Clinical Trials (RBR-4fgknb) at http://www.ensaiosclinicos.gov.br.

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Fig. 1: Design of the experimental sessions.
Fig. 2: Post-intervention responses.

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Data availability

Final study data is available by written request to the investigators.

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Acknowledgements

We are grateful to all the subjects that participated in this investigation. The study was financially supported by: FAPESP (2018/23653-3; 2019/02649-0; 2018/12390-1; 2018/19151-8), CNPq (304436/2018-6) and CAPES (0001).

Funding

The study received financial support from the FAPESP under grants (2018/23653-3; 2019/02649-0; 2018/12390-1; 2018/19151-8), from the CNPq under grant (304436/2018-6) and from CAPES under grant (0001).

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Author notes

  1. These authors contributed equally: Laura Oliveira-Silva, Rafael Yokoyama Fecchio.

Authors and Affiliations

  1. Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil

    Laura Oliveira-Silva, Rafael Yokoyama Fecchio, Natan Daniel da Silva Junior, Julio Cesar Silva de Sousa & Cláudia Lúcia de Moraes Forjaz

  2. Unidade de Hipertensão, Disciplina de Nefrologia, Hospital das Clínicas, HCFMUSP, Universidade de São Paulo, São Paulo, Brazil

    Andrea Pio-Abreu, Giovânio Vieira da Silva & Luciano Ferreira Drager

  3. Unidade de Hipertensão, Instituto do Coração (InCor), Hospital das Clínicas, HCFMUSP, Universidade de São Paulo, São Paulo, Brazil

    Luciano Ferreira Drager

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Contributions

LO: data collection; analysed data; RYF: study conception, data collection; designed research; analysed data; wrote the manuscript; NSJ: data collection; APA: data collection and designed research; GVS: data collection and designed research; LFD: data collection and designed research; JCSS: study conception, data collection; designed research; analysed data; CLMF: study conception, designed research, approved the final version of the manuscript.

Corresponding author

Correspondence to Cláudia Lúcia de Moraes Forjaz.

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Competing interests

The authors declare no competing interests.

Ethics approval

The current data was conducted in accordance with the principles of the Declaration of Helsinki. This study is a part of a bigger study that was approved by the local Ethics Committee (process 2.870.688) and included at Brazilian Clinical Trials register [RBR-4fgknb at http://www.ensaiosclinicos.gov.br].

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Oliveira-Silva, L., Fecchio, R.Y., Silva Junior, N.D.d. et al. Post-dynamic, isometric and combined resistance exercise responses in medicated hypertensive men. J Hum Hypertens 38, 52–61 (2024). https://doi.org/10.1038/s41371-023-00859-1

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