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Current Genomics

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ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

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Circular RNA Translation in Cardiovascular Diseases

Author(s): Lijun Wang, Xinxin Cui, Fei Jiang, Yuxue Hu, Wensi Wan, Guoping Li, Yanjuan Lin* and Junjie Xiao*

Volume 24, Issue 2, 2023

Published on: 13 September, 2023

Page: [66 - 71] Pages: 6

DOI: 10.2174/1389202924666230911121358

Abstract

Circular RNAs (circRNAs) are a class of endogenous functional RNA generated by backsplicing. Recently, circRNAs have been found to have certain coding potential. Proteins/peptides translated from circRNAs play essential roles in various diseases. Here, we briefly summarize the basic knowledge and technologies that are usually applied to study circRNA translation. Then, we focus on the research progress of circRNA translation in cardiovascular diseases and discuss the perspective and future direction of translatable circRNA study in cardiovascular diseases.

Keywords: circRNAs, cardiovascular diseases, internal ribosome entry sites (IRES), RNA m6A, proteins, ribosomal scanning.

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