Abstract
Glutamate in monosodium glutamate (MSG), which is widely used in the food industry, has an important role in major brain functions such as memory, learning, synapse formation, and stabilization. However, extensive use of MSG has been linked with neurotoxicity. Therefore, in addition to clarifying the underlying mechanisms of MSG-induced neurotoxicity, it is also important to determine safe agents that can diminish the damage caused by MSG. Tannic acid (TA) is a naturally occurring plant polyphenol that exhibits versatile physiological effects such as anti-inflammatory, anti-carcinogenic, antioxidant, and radical scavenging. This study was conducted to assess the neurotoxic and neuroprotective effects of these two dietary components in the rat cerebral cortex. Twenty-four Sprague Dawley rats were divided into 4 equal groups and were treated with MSG (2 g/kg) and TA (50 mg/kg) alone and in combination for 3 weeks. Alterations in oxidative stress indicators (MDA and GSH) were measured in the cortex tissues. In addition, changes in enzymatic activities and gene expression patterns of antioxidant system components (GST, GPx, CAT, and SOD) were investigated. Furthermore, mRNA expressions of FoxO transcription factors (Foxo1 and Foxo3) and apoptotic markers (Casp3 and Casp9) were assessed. Results revealed that dietary TA intake significantly rehabilitated MSG-induced dysregulation in cortical tissue by regulating redox balance, cellular homeostasis, and apoptosis. The present study proposes that MSG-induced detrimental effects on cortical tissue are potentially mitigated by TA via modulation of oxidative stress, cell metabolism, and programmed cell death.
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Abbreviations
- ANOVA:
-
Analysis of variance
- CAT:
-
Catalase
- cDNA:
-
Complementary DNA
- GPx:
-
Glutathione peroxidase
- GSH:
-
Glutathione
- GST:
-
Glutathione S-transferase
- MDA:
-
Malondialdehyde
- MSG:
-
Monosodium glutamate
- qPCR:
-
Quantitative polymerase chain reaction
- RNA:
-
Ribonucleic acid
- SOD:
-
Superoxide dismutase
- TA:
-
Tannic acid
References
Abe H, Abe K (2022) PCR-based profiling of transcription factor activity in vivo by a virus-based reporter battery. iScience 25(3):103927. https://doi.org/10.1016/j.isci.2022.103927
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215(3):403–410. https://doi.org/10.1016/S0022-2836(05)80360-2
Alzheimer Disease International (ADI) (2022) Life after diagnosis: Navigating treatment, care and support. World Alzheimer Report
Apak R, Calokerinos A, Gorinstein S, Segundo MA, Hibbert DB, Gulcin I, Cekic SD, Guclu K, Ozyurek M, Celik SE, Magalhaes LM, Arancibia-Avila P (2022) Methods to evaluate the scavenging activity of antioxidants toward reactive oxygen and nitrogen species (IUPAC Technical Report). Pure Appl Chem 94(1):87–144. https://doi.org/10.1515/pac-2020-0902
Asai H, Ohkawa N, Saitoh Y, Ghandour K, Murayama E, Nishizono H, Matsuo M, Hirayama T, Kaneko R, Muramatsu SI, Yagi T, Inokuchi K (2020) Pcdhbeta deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination. Mol Brain 13(1):7. https://doi.org/10.1186/s13041-020-0547-z
Azimullah S, Meeran MFN, Ayoob K, Arunachalam S, Ojha S, Beiram R (2023) Tannic acid mitigates rotenone-induced dopaminergic neurodegeneration by inhibiting inflammation, oxidative stress, apoptosis, and glutamate toxicity in rats. Int J Mol Sci 24(12). https://doi.org/10.3390/ijms24129876
Barabasi AL, Oltvai ZN (2004) Network biology: understanding the cell’s functional organization. Nat Rev Genet 5(2):101–113. https://doi.org/10.1038/nrg1272
Beydemir S, Demir Y (2017) Antiepileptic drugs: Impacts on human serum paraoxonase-1. J Biochem Mol Toxicol 31(6). https://doi.org/10.1002/jbt.21889
Beyreuther K, Biesalski HK, Fernstrom JD, Grimm P, Hammes WP, Heinemann U, Kempski O, Stehle P, Steinhart H, Walker R (2007) Consensus meeting: monosodium glutamate — an update. Eur J Clin Nutr 61(3):304–313. https://doi.org/10.1038/sj.ejcn.1602526
Bhatti GK, Reddy AP, Reddy PH, Bhatti JS (2019) Lifestyle modifications and nutritional interventions in aging-associated cognitive decline and Alzheimer’s disease. Front Aging Neurosci 11:369. https://doi.org/10.3389/fnagi.2019.00369
Bolukbasi E, Woodling NS, Ivanov DK, Adcott J, Foley A, Rajasingam A, Gittings LM, Aleyakpo B, Niccoli T, Thornton JM, Partridge L (2021) Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proc Natl Acad Sci USA 118(8). https://doi.org/10.1073/pnas.2011491118
Bora RE, Genc Bilgicli H, Uc EM, Alagoz MA, Zengin M, Gulcin I (2022) Synthesis, characterization, evaluation of metabolic enzyme inhibitors and in silico studies of thymol based 2-amino thiol and sulfonic acid compounds. Chem Biol Interact 366:110134. https://doi.org/10.1016/j.cbi.2022.110134
Carithers LJ, Moore HM (2015) The Genotype-Tissue Expression (GTEx) Project. Biopreserv Biobank 13(5):307–308. https://doi.org/10.1089/bio.2015.29031.hmm
Ceylan H (2021a) A bioinformatics approach for identifying potential molecular mechanisms and key genes involved in COVID-19 associated cardiac remodeling. Gene Rep 24:101246. https://doi.org/10.1016/j.genrep.2021.101246
Ceylan H (2021b) Identification of hub genes associated with obesity-induced hepatocellular carcinoma risk based on integrated bioinformatics analysis. Med Oncol 38(6):63. https://doi.org/10.1007/s12032-021-01510-0
Ceylan H (2022) Integrated bioinformatics analysis to identify alternative therapeutic targets for Alzheimer’s disease: insights from a synaptic machinery perspective. J Mol Neurosci 72(2):273–286. https://doi.org/10.1007/s12031-021-01893-9
Ceylan H, Budak H, Kocpinar EF, Baltaci NG, Erdogan O (2019) Examining the link between dose-dependent dietary iron intake and Alzheimer’s disease through oxidative stress in the rat cortex. J Trace Elem Med Biol 56:198–206. https://doi.org/10.1016/j.jtemb.2019.09.002
Ceylan H, Erdogan O (2017) Cloning, expression, and characterization of human brain acetylcholinesterase in Escherichia coli using a SUMO fusion tag. Turk J Biol 41(1):77–87. https://doi.org/10.3906/biy-1602-83
Chen X, Guo C, Kong J (2012) Oxidative stress in neurodegenerative diseases. Neural Regen Res 7(5):376–385. https://doi.org/10.3969/j.issn.1673-5374.2012.05.009
de la Torre-Ubieta L, Gaudilliere B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmuller J, Schuller U, Salih DA, Rowitch D, Brunet A, Bonni A (2010) A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes Dev 24(8):799–813. https://doi.org/10.1101/gad.1880510
Du S, Zheng H (2021) Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases. Cell Biosci 11(1):188. https://doi.org/10.1186/s13578-021-00700-7
Ferruzzi MG, Lobo JK, Janle EM, Cooper B, Simon JE, Wu QL, Welch C, Ho L, Weaver C, Pasinetti GM (2009) Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer’s disease. J Alzheimers Dis 18(1):113–124. https://doi.org/10.3233/JAD-2009-1135
Fostinelli S, De Amicis R, Leone A, Giustizieri V, Binetti G, Bertoli S, Battezzati A, Cappa SF (2020) Eating behavior in aging and dementia: the need for a comprehensive assessment. Front Nutr 7:604488. https://doi.org/10.3389/fnut.2020.604488
Gilley J, Coffer PJ, Ham J (2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162(4):613–622. https://doi.org/10.1083/jcb.200303026
Goel P, Chakrabarti S, Goel K, Bhutani K, Chopra T, Bali S (2022) Neuronal cell death mechanisms in Alzheimer’s disease: An insight. Front Mol Neurosci 15:937133. https://doi.org/10.3389/fnmol.2022.937133
Gonul Baltaci N, Guler C, Ceylan H, Kalin SN, Adem S, Kocpinar EF, Erdogan O, Budak H (2018) In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen. J Biochem Mol Toxicol e22229. https://doi.org/10.1002/jbt.22229
Guarnieri G, Sarchielli E, Vannelli GB, Morelli A (2018) Cell-based therapy in Alzheimer’s disease: Can human fetal cholinergic neurons “untangle the skein”? Neural Regen Res 13(12):2105–2107. https://doi.org/10.4103/1673-5374.241459
Gulcin I, Huyut Z, Elmastas M, Aboul-Enein HY (2010) Radical scavenging and antioxidant activity of tannic acid. Arab J Chem 3(1):43–53. https://doi.org/10.1016/j.arabjc.2009.12.008
Hazarika I, Mukundan GK, Sundari PS (2022) Neuroprotective effect of hydrocotyle sibthorpioides against monosodium glutamate-induced excitotoxicity. Nat Prod Res 36(23):6156–6159. https://doi.org/10.1080/14786419.2022.2057493
Hazzaa SM, El-Roghy ES, Abd Eldaim MA, Elgarawany GE (2020) Monosodium glutamate induces cardiac toxicity via oxidative stress, fibrosis, and P53 proapoptotic protein expression in rats. Environ Sci Pollut Res Int 27(16):20014–20024. https://doi.org/10.1007/s11356-020-08436-6
Hernandez Bautista RJ, Mahmoud AM, Konigsberg M, Guerrero NELD (2019) Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants. Biomed Pharmacother 111:503–516. https://doi.org/10.1016/j.biopha.2018.12.108
Jain V, Langham MC, Wehrli FW (2010) MRI estimation of global brain oxygen consumption rate. J Cereb Blood Flow Metab 30(9):1598–1607. https://doi.org/10.1038/jcbfm.2010.49
Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M, Bork P, von Mering C (2009) STRING 8—a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 37(Database issue):D412–416. https://doi.org/10.1093/nar/gkn760
Kim DY, Hwang I, Muller FL, Paik JH (2015) Functional regulation of FoxO1 in neural stem cell differentiation. Cell Death Differ 22(12):2034–2045. https://doi.org/10.1038/cdd.2015.123
Kocpinar EF, Baltaci NG, Akkemik E, Budak H (2023) Depletion of Tip60/Kat5 affects the hepatic antioxidant system in mice. J Cell Biochem 124(1):103–117. https://doi.org/10.1002/jcb.30348
Kocpinar EF, Gonul Baltaci N, Ceylan H, Kalin SN, Erdogan O, Budak H (2020) Effect of a prolonged dietary iron intake on the gene expression and activity of the testicular antioxidant defense system in rats. Biol Trace Elem Res 195(1):135–141. https://doi.org/10.1007/s12011-019-01817-0
Koohpeyma F, Siri M, Allahyari S, Mahmoodi M, Saki F, Dastghaib S (2021) The effects of L-carnitine on renal function and gene expression of caspase-9 and Bcl-2 in monosodium glutamate-induced rats. BMC Nephrol 22(1):162. https://doi.org/10.1186/s12882-021-02364-4
Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419(6904):316–321. https://doi.org/10.1038/nature01036
Kouzuki M, Taniguchi M, Suzuki T, Nagano M, Nakamura S, Katsumata Y, Matsumoto H, Urakami K (2019) Effect of monosodium L-glutamate (umami substance) on cognitive function in people with dementia. Eur J Clin Nutr 73(2):266–275. https://doi.org/10.1038/s41430-018-0349-x
Kumar A, Gupta S, Sharma P, Prasad R, Pal A (2019) In silico method for identification of novel copper and iron metabolism proteins in various neurodegenerative disorders. Neurotoxicology 73:50–57. https://doi.org/10.1016/j.neuro.2019.02.020
Leandrou S, Lamnisos D, Mamais I, Kyriacou PA, Pattichis CS, Alzheimer’s D, & Neuroimaging I. (2020) Assessment of Alzheimer’s disease based on texture analysis of the entorhinal cortex. Front Aging Neurosci 12:176. https://doi.org/10.3389/fnagi.2020.00176
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402–408. https://doi.org/10.1006/meth.2001.1262
Lovden M, Xu W, Wang HX (2013) Lifestyle change and the prevention of cognitive decline and dementia: what is the evidence? Curr Opin Psychiatry 26(3):239–243. https://doi.org/10.1097/YCO.0b013e32835f4135
Medic-Saric M, Rastija V, Bojic M, Males Z (2009) From functional food to medicinal product: systematic approach in analysis of polyphenolics from propolis and wine. Nutr J 8:33. https://doi.org/10.1186/1475-2891-8-33
Mitsuda N, Ohme-Takagi M (2009) Functional analysis of transcription factors in Arabidopsis. Plant Cell Physiol 50(7):1232–1248. https://doi.org/10.1093/pcp/pcp075
Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T (2012) Tannic acid is a natural beta-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J Biol Chem 287(9):6912–6927. https://doi.org/10.1074/jbc.M111.294025
Omogbiya AI, Ben-Azu B, Eduviere AT, Eneni AO, Nwokoye PO, Ajayi AM, Umukoro S (2021) Monosodium glutamate induces memory and hepatic dysfunctions in mice: ameliorative role of Jobelyn((R)) through the augmentation of cellular antioxidant defense machineries. Toxicol Res 37(3):323–335. https://doi.org/10.1007/s43188-020-00068-9
Oyeyinka BO, Afolayan AJ (2022) Suitability of banana and plantain fruits in modulating neurodegenerative diseases: implicating the in vitro and in vivo evidence from neuroactive narratives of constituent biomolecules. Foods 11(15). https://doi.org/10.3390/foods11152263
Oztay F, Tunali S, Kayalar O, Yanardag R (2020) The protective effect of vitamin U on valproic acid-induced lung toxicity in rats via amelioration of oxidative stress. J Biochem Mol Toxicol 34(12):e22602. https://doi.org/10.1002/jbt.22602
Pai AA, Luca F (2019) Environmental influences on RNA processing: biochemical, molecular and genetic regulators of cellular response. Wiley Interdiscip Rev RNA 10(1):e1503. https://doi.org/10.1002/wrna.1503
Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5(5):540–553. https://doi.org/10.1016/j.stem.2009.09.013
Park CH, Choi SH, Piao Y, Kim S, Lee YJ, Kim HS, Jeong SJ, Rah JC, Seo JH, Lee JH, Chang K, Jung YJ, Suh YH (2000) Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice. Toxicol Lett 115(2):117–125. https://doi.org/10.1016/s0378-4274(00)00188-0
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP (2018) Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease. Hum Mol Genet 27(14):2502–2516. https://doi.org/10.1093/hmg/ddy154
Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A (2009) FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell 5(5):527–539. https://doi.org/10.1016/j.stem.2009.09.014
Sarchielli E, Guarnieri G, Idrizaj E, Squecco R, Mello T, Comeglio P, Gallina P, Maggi M, Vannelli GB, Morelli A (2020) The G protein-coupled oestrogen receptor, GPER1, mediates direct anti-inflammatory effects of oestrogens in human cholinergic neurones from the nucleus basalis of Meynert. J Neuroendocrinol 32(3):e12837. https://doi.org/10.1111/jne.12837
Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanza-Martinez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN, & International Society for Nutritional Psychiatry R (2015) Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry 2(3):271–274. https://doi.org/10.1016/S2215-0366(14)00051-0
Sayre LM, Perry G, Smith MA (2008) Oxidative stress and neurotoxicity. Chem Res Toxicol 21(1):172–188. https://doi.org/10.1021/tx700210j
Schoenfeld MA, Neuer G, Tempelmann C, Schussler K, Noesselt T, Hopf JM, Heinze HJ (2004) Functional magnetic resonance tomography correlates of taste perception in the human primary taste cortex. Neuroscience 127(2):347–353. https://doi.org/10.1016/j.neuroscience.2004.05.024
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498–2504. https://doi.org/10.1101/gr.1239303
Siddique YH, Rahul, Ara G, Afzal M, Varshney H, Gaur K, Subhan I, Mantasha I, Shahid M (2022) Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer’s disease. Chem Biol Interact 366:110120. https://doi.org/10.1016/j.cbi.2022.110120
Soininen H, Solomon A, Visser PJ, Hendrix SB, Blennow K, Kivipelto M, Hartmann T, LipiDiDiet clinical study g. (2017) 24-month intervention with a specific multinutrient in people with prodromal Alzheimer’s disease (LipiDiDiet): a randomised, double-blind, controlled trial. Lancet Neurol 16(12):965–975. https://doi.org/10.1016/S1474-4422(17)30332-0
Soleimani A, Keivani N, Lotfipour S, Abolhasani S, Valizadeh S, Behniafar H (2022) Promising effects of herbal compounds against strongyloidiasis: a systematic review. J Parasit Dis 46(4):1192–1203. https://doi.org/10.1007/s12639-022-01532-z
Suleyman H, Cadirci E, Albayrak A, Polat B, Halici Z, Koc F, Hacimuftuoglu A, Bayir Y (2009) Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats. Chem Biol Interact 180(2):318–324. https://doi.org/10.1016/j.cbi.2009.03.002
Tampi RR, Jeste DV (2022) Dementia is more than memory loss: neuropsychiatric symptoms of dementia and their nonpharmacological and pharmacological management. Am J Psychiatry 179(8):528–543. https://doi.org/10.1176/appi.ajp.20220508
Thongsepee N, Martviset P, Chantree P, Sornchuer P, Sangpairoj K, Prathaphan P, Ruangtong J, Hiranyachattada S (2022) Daily consumption of monosodium glutamate pronounced hypertension and altered renal excretory function in normotensive and hypertensive rats. Heliyon 8(10):e10972. https://doi.org/10.1016/j.heliyon.2022.e10972
Tuzmen MN, Yucel NC, Kalburcu T, Demiryas N (2015) Effects of curcumin and tannic acid on the aluminum- and lead-induced oxidative neurotoxicity and alterations in NMDA receptors. Toxicol Mech Methods 25(2):120–127. https://doi.org/10.3109/15376516.2014.997947
Untergasser A, Cutcutache I, Koressaar T, Ye J, Faircloth BC, Remm M, Rozen SG (2012) Primer3—-new capabilities and interfaces. Nucleic Acids Res 40(15):e115. https://doi.org/10.1093/nar/gks596
Vauzour D (2012) Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev 914273. https://doi.org/10.1155/2012/914273
Wang J, Wang F, Mai D, Qu S (2020) Molecular mechanisms of glutamate toxicity in Parkinson’s disease. Front Neurosci 14:585584. https://doi.org/10.3389/fnins.2020.585584
Winiarska-Mieczan A (2013) Protective effect of tannic acid on the brain of adult rats exposed to cadmium and lead. Environ Toxicol Pharmacol 36(1):9–18. https://doi.org/10.1016/j.etap.2013.02.018
World Health Organization (WHO) (2021) Global status report on the public health response to dementia. WHO Geneva: World Health Organization
Wu D, Chen Q, Chen X, Han F, Chen Z, Wang Y (2023) The blood-brain barrier: structure, regulation, and drug delivery. Signal Transduct Target Ther 8(1):217. https://doi.org/10.1038/s41392-023-01481-w
Wu Y, Zhong L, Yu Z, Qi J (2019) Anti-neuroinflammatory effects of tannic acid against lipopolysaccharide-induced BV2 microglial cells via inhibition of NF-kappaB activation. Drug Dev Res 80(2):262–268. https://doi.org/10.1002/ddr.21490
Yang S, Pang L, Dai W, Wu S, Ren T, Duan Y, Zheng Y, Bi S, Zhang X, Kong J (2021) Role of forkhead box O proteins in hepatocellular carcinoma biology and progression (Review). Front Oncol 11:667730. https://doi.org/10.3389/fonc.2021.667730
Yesilkent EN, Ceylan H (2022) Investigation of the multi-targeted protection potential of tannic acid against doxorubicin-induced kidney damage in rats. Chem Biol Interact 365:110111. https://doi.org/10.1016/j.cbi.2022.110111
Zhou Y, Danbolt NC (2014) Glutamate as a neurotransmitter in the healthy brain. J Neural Transm (vienna) 121(8):799–817. https://doi.org/10.1007/s00702-014-1180-8
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The present study was supported by the Ataturk University Scientific Research Project Coordination Unit (Grant Number: FYL-2021–9271).
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HC conceived the study and designed experiments. HC and MSK performed experiments and analyzed the results. HC wrote the main manuscript. All authors reviewed and edited the final manuscript.
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Karagac, M.S., Ceylan, H. Neuroprotective Potential of Tannic Acid Against Neurotoxic Outputs of Monosodium Glutamate in Rat Cerebral Cortex. Neurotox Res 41, 670–680 (2023). https://doi.org/10.1007/s12640-023-00667-y
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DOI: https://doi.org/10.1007/s12640-023-00667-y