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Online Diagnosis and Self-Recovery of Faulty Cells in Daisy-Chained MEDA Biochips Using Functional Actuation Patterns

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Abstract

Digital microfluidic biochips are becoming an alternative for laboratory experiments like DNA analysis, immunoassays and safety clinical diagnostics. Reliability is a critical issue for them. MEDA biochips are a new kind of digital microfluidic biochips which are based on microelectrode-dot-array. Daisy chain is the key component of a MEDA biochip, if there is one fault exist in one cell, the whole daisy chain is broken down, the biochip has to be discarded. Therefore, daisy chain’s reliability is especially critical. The paper proposes a new daisy chain online repair scheme, where the cells of daisy chain are repaired during the time of the functional data shifted in. The emphasis is on identifying and repairing the fail daisy chain cells when bioassay is running, without any influence on the executing bioassay. Besides, the online self-repair scheme does not contribute to electrode degradation, and takes no additional time. The experimental results also prove the efficiency of the scheme.

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Funding

The research work was supported by the National Natural Science Foundation of China (No.62241404) and the Scientific Research Foundation of the Educational Commission of Jiangxi Province (No. GJJ210501).

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  1. School of Software and Internet of Things Engineering, Jiangxi University of Finance and Economics, Nanchang, 330003, JiangXi, China

    Ling Zhang

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  1. Ling Zhang
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Correspondence to Ling Zhang.

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The author had received funding for this research from the following sources National Natural Science Foundation of China (No.62241404) and the Scientific Research Foundation of the Educational Commission of Jiangxi Province (No. GJJ210501). The author has no relevant financial or non-financial interests to disclose. The author has no competing interests to declare that are relevant to the content of this article.

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Zhang, L. Online Diagnosis and Self-Recovery of Faulty Cells in Daisy-Chained MEDA Biochips Using Functional Actuation Patterns. J Electron Test 39, 521–534 (2023). https://doi.org/10.1007/s10836-023-06081-8

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  • DOI: https://doi.org/10.1007/s10836-023-06081-8

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