Abstract
Background
Bladder cancer (BC) originating from the bladder mucosa is a malignant tumor of the genitourinary system. Long non-coding RNAs (lncRNAs) can participate in cell proliferation and differentiation at multiple levels, and lncRNA dysregulation involves in the processes of malignant tumors.
Methods
Focused on lncRNA small nucleolar RNA host gene 12 (SNHG12) and its target miR-143-3p, the specific mechanism related to BC was discovered. SNHG12 and miR-143-3p expression in BC samples was checked, together with the association with the malignant activities of BC cells.
Results
As texted, SNHG12 expression went upward and miR-143-3p expression went downward in BC. SNHG12 depletion or miR-143-3p over-expression was causal for the suppression of BC cell activities. SNHG12 expression was directly associated with miR-143-3p expression. Ablating miR-143-3p abrogated changes in BC cell function induced by SNHG12 depletion.
Conclusions
Generally, SNHG12/miR-143-3p induces the malignant activities of BC cells.
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Availability of data and materials
Data are available from the corresponding author on request.
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This work was supported by Health Medicine Science and Technology Plan Project of Zhejiang Province, China (Grant No. 2021KY603).
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LC designed the research study. LC and CF performed the research. WZ and WXY provided help and advice. CF and WZ analyzed the data. LC and WXY wrote the manuscript. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript.
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Li Chen declares that he has no conflict of interest. Chao Feng declares that he has no conflict of interest. Wei Zhou declares that he has no conflict of interest. WenXin Ye declares that he has no conflict of interest.
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All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All subjects were approved by Tongde Hospital of Zhejiang Province (No. (2021) 018). Written informed consent was obtained from each subject.
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Chen, L., Feng, C., Zhou, W. et al. Molecular mechanism of long non-coding RNA SNHG12 regulating bladder cancer cell activities. Mol. Cell. Toxicol. (2023). https://doi.org/10.1007/s13273-023-00391-w
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DOI: https://doi.org/10.1007/s13273-023-00391-w