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Effects of Quercetin on Ovarian Toxicity Induced by Dietary Monosodium Glutamate

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Abstract

Monosodium glutamate (MSG) is globally used to impart flavor in cooking and to improve palatability. This work assessed the protective effects of quercetin (QU) on alterations associated with exposure to MSG. Thirty female rats were equally sorted into five groups: G (I) received water and was considered the healthy control, G (II) received corn oil orally, G (III) received QU orally for 30 days, G (IV) received MSG as an oral solution (15 mg/kg body weight) for 30 days, while G (V) was given MSG and QU simultaneously. Alterations in the levels of (serum estrogen, lipid peroxidation, and glutathione), and the activity of (glutathione peroxidase, and superoxide dismutase), ovarian histological lesions, and ultrastructural changes induced by MSG administration were remarkably ameliorated on treatment with QU (14 mg/kg b. wt.). Thus, due to its antioxidant characteristics, QU might be utilized in combination with MSG to relieve ovarian toxicity brought on by MSG.

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Authors and Affiliations

  1. Histology and Genetics Division, Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

    Hadeer Mohamed Hamdalla, Rasha Rashad Ahmed, Sanaa Rida Galaly & Manal Abdul-Hamid

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Correspondence to Manal Abdul-Hamid.

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Conflict of interest. Research workers claim that they have no known competing financial profits or personal relationships that could have seemed to influence the work delivered in this paper.

Statement on the welfare of animals. All treatments involving animals were carried out in accordance with the criteria and regulations established by the Animal Ethics Committee of the Zoology Department, Faculty of Science, Beni-Suef University (approval number: BSU/FS/ 2015/9).

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Abbreviations: H&E—hematoxylin and eosin, MSG—monosodium glutamate, b. wt.—body weight, QU—quercetin, MDA— malondialdehyde, LPO—lipid peroxidation, GSH—Glutathione, GSH-Px—glutathione peroxidase, SOD—superoxide dismutase, ROS—reactive oxygen species.

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Hamdalla, H.M., Ahmed, R.R., Galaly, S.R. et al. Effects of Quercetin on Ovarian Toxicity Induced by Dietary Monosodium Glutamate. Cell Tiss. Biol. 17, 543–556 (2023). https://doi.org/10.1134/S1990519X2305005X

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