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MicroRNA-495: a therapeutic and diagnostic tumor marker

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Abstract

Therapeutic and diagnostic progresses have significantly reduced the mortality rate among cancer patients during the last decade. However, there is still a high rate of mortality among cancer patients. One of the important reasons involved in the high mortality rate is the late diagnosis in advanced tumor stages that causes the failure of therapeutic strategies in these patients. Therefore, investigating the molecular mechanisms involved in tumor progression has an important role in introducing the efficient early detection markers. MicroRNAs (miRNAs) as stable factors in body fluids are always considered as non-invasive diagnostic and prognostic markers. In the present review, we investigated the role of miR-495 in tumor progression. It has been reported that miR-495 has mainly a tumor suppressor function through the regulation of transcription factors and tyrosine kinases as well as cellular processes such as multidrug resistance, chromatin remodeling, and signaling pathways. This review can be an effective step towards introducing the miR-495 as a non-invasive diagnostic/prognostic marker as well as a suitable target in tumor therapy.

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Authors and Affiliations

  1. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhosein Maharati, Iman Akhlaghipour & Amir Sadra Zangouei

  2. Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Faezeh Tolue Ghasaban & Meysam Moghbeli

  3. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Faezeh Tolue Ghasaban, Negin Taghehchian & Meysam Moghbeli

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  1. Amirhosein Maharati
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  2. Faezeh Tolue Ghasaban
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  3. Iman Akhlaghipour
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  4. Negin Taghehchian
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  5. Amir Sadra Zangouei
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AM, FTG, ASZ, and IA were involved in drafting. ASZ and NT were involved in search strategy and figures preparation. MM designed and supervised the project. All authors read and approved the final manuscript.

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Correspondence to Meysam Moghbeli.

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Maharati, A., Tolue Ghasaban, F., Akhlaghipour, I. et al. MicroRNA-495: a therapeutic and diagnostic tumor marker. J Mol Histol 54, 559–578 (2023). https://doi.org/10.1007/s10735-023-10159-0

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