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A method of fabrication of porous carbonate apatite artificial bone for biomedical application

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Abstract

Among the various bone substitutes, carbonate apatite (CO3Ap) has received significant attention in the field of hard tissue regeneration due to its similarity in chemical composition to natural bone and its osteoconductivity and bioresorbability. This study aimed to develop a cost-effective method for fabricating porous CO3Ap blocks while maintaining a balance between porosity and mechanical properties. The level of interconnectivity in the porous structure was achieved by adjusting the pore volume fractions of the starting materials. The phase and microstructure characteristics of the porous CO3Ap blocks were assessed using techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The diametral tensile strength (DTS) of the blocks was determined using a universal testing machine. The results demonstrated that the mechanical strength of the blocks stayed within a range that was suitable for handling properties. This advantage allows the porous blocks to withstand initial stress during implantation procedures or in the early stages of defect healing.

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Acknowledgements

We acknowledge the support of time and facilities from Ho Chi Minh City University of Technology (HCMUT) for this study.

Funding

This research is funded by Vietnam National University Ho Chi Minh City (VNU-HCM) under grant number C-2022–20-24.

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Authors and Affiliations

  1. Division of Biomedical Engineering, Faculty of Applied Science, Ho Chi Minh City University of Technology, Ho Chi Minh City, 70000, Vietnam

    Nguyen Xuan Thanh Tram

  2. Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, 70000, Vietnam

    Nguyen Xuan Thanh Tram

  3. Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City, Ho Chi Minh City, 700000, Vietnam

    Cao Xuan Thang

  4. Department of Biomaterials, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

    Kunio Ishikawa

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  1. Nguyen Xuan Thanh Tram
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  2. Cao Xuan Thang
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  3. Kunio Ishikawa
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Nguyen, X.T.T., Cao, X.T. & Kunio, I. A method of fabrication of porous carbonate apatite artificial bone for biomedical application. J Aust Ceram Soc 60, 399–406 (2024). https://doi.org/10.1007/s41779-023-00954-z

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