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Biologically Active Palladium(II), Zinc(II), and Copper(II) Complexes with Terpene Ligands as Potential Pharmaceutical Drugs

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Abstract

A final review of the results of studies of versatile biological activities (in vitro) of chiral metal complexes with benzylamine and ethylenediamine derivatives of terpenes is presented. The cytotoxic profiles of palladacycles containing a Pd–C bond and palladium and zinc chelate complexes were determined. For a number of compounds, the possible mechanisms of potential anticancer action were analyzed, such as modulation of mitochondrial functioning and effect on the parameters of glycolytic function of tumor cells. The antibacterial and antifungal activities of palladium complexes of different types and copper chelate complexes were investigated. A correlation between high antimicrobial activity and antioxidant properties was found for a number of copper complexes. The material is supplemented by an extended analysis of publications in relevant subjects.

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ACKNOWLEDGMENTS

The anticancer activity studies of metal complexes were carried out at the Institute of Physiologically Active Compounds, Federal Research Center of the Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences. The antibacterial and antifungal activities of palladium(II) complexes were assessed within the framework of the CO-ADD international project (Australia); those of copper(II) complexes were investigated at the Bach Institute of Biochemistry, Federal Research Center of Biotechnology, Russian Academy of Sciences. The antioxidant activities of copper(II) complexes were measured using various assay systems at the Institute of Biology, Komi Science Center, Ural Branch, Russian Academy of Sciences. All of the obtained results were included in the relevant publications. The authors are grateful to all co-authors.

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The preparation of this review was supported by ongoing institutional funding. No additional grants were obtained.

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Authors and Affiliations

  1. Institute of Chemistry, Komi Science Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia

    Ya. A. Gur’eva, O. A. Zalevskaya & A. V. Kuchin

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  1. Ya. A. Gur’eva
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  2. O. A. Zalevskaya
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  3. A. V. Kuchin
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Correspondence to Ya. A. Gur’eva.

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Translated by Z. Svitanko

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Gur’eva, Y.A., Zalevskaya, O.A. & Kuchin, A.V. Biologically Active Palladium(II), Zinc(II), and Copper(II) Complexes with Terpene Ligands as Potential Pharmaceutical Drugs. Russ J Coord Chem 49, 631–651 (2023). https://doi.org/10.1134/S1070328423700665

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