1887

Journal of Medical Microbiology logo

Volume 72, Issue 10

Avian reovirus: a furious and fast evolving pathogen Open Access

This article is part of the JMM Profiles collection.

Graphical Abstract

 Graphical abstract 

Avian reovirus (ARV) can be transmitted vertically and horizontally. Pathogenic strains cause arthritis/tenosynovitis (depicted as red hock joints, and splayed legs), and can play a role in malabsorption syndrome in chickens. Contaminated fomites can be a dissemination source in poultry facilities. Figure generated with BioRender.

 

Abstract

Avian reoviruses (ARVs) have a significant economic impact on the poultry industry, affecting commercial and backyard flocks. Spread feco-orally, or vertically, many do not cause morbidity, but pathogenic strains can contribute to several diseases, including tenosynovitis/arthritis, which is clinically the most significant. The last decade has seen a surge in cases in the US, and due to ongoing evolution, seven genotypic clusters have now been identified. Control efforts include strict biosecurity and vaccination with commercial and autogenous vaccines. Research priorities include improving understanding of pathogenesis and developing new vaccines guided by ongoing molecular and serologic surveillance.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): ARV , avian orthoreovirus , immunosuppression , malabsorption , poultry and viral arthritis-tenosynovitis
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.001761
2023-10-06
2024-04-27
Loading full text...

Full text loading...

/deliver/fulltext/jmm/72/10/jmm001761.html?itemId=/content/journal/jmm/10.1099/jmm.0.001761&mimeType=html&fmt=ahah

References

  1. Fahey JE, Crawley JF. Studies on chronic respiratory disease of chickens II. Isolation of a virus. Can J Comp Med Vet Sci 1954; 18:13–21 [PubMed]
     [Google Scholar]
  2. NO O, DA M. Infectious synovitis control by medication; effect of strain differences and pleuropneumonia-like organisms. Am J Vet Res 1957; 18:735–739
     [Google Scholar]
  3. Walker ER, Friedman MH, Olson NO. Electron microscopic study of an avian reovirus that causes arthritis. J Ultrastruct Res 1972; 41:67–79 [View Article] [PubMed]
     [Google Scholar]
  4. van der Heide L, Kalbac M, Brustolon M. Development of an attenuated apathogenic reovirus vaccine against viral arthritis/tenosynovitis. Avian Dis 1983; 27:698–706 [PubMed]
     [Google Scholar]
  5. Jones RC, Kibenge FSB. Reovirus-induced tenosynovitis in chickens: the effect of breed. Avian Pathol 1984; 13:511–528 [View Article] [PubMed]
     [Google Scholar]
  6. Pitcovski J, Goyal SM. Avian reovirus infections. In Diseases of Poultry 2020 [View Article]
     [Google Scholar]
  7. Dandár E, Bálint A, Kecskeméti S, Szentpáli-Gavallér K, Kisfali P et al. Detection and characterization of a divergent avian reovirus strain from a broiler chicken with central nervous system disease. Arch Virol 2013; 158:2583–2588 [View Article] [PubMed]
     [Google Scholar]
  8. Benavente J, Martínez-Costas J. Avian reovirus: structure and biology. Virus Res 2007; 123:105–119 [View Article] [PubMed]
     [Google Scholar]
  9. Bruhn S, Bruckner L, Ottiger H-P. Application of RT-PCR for the detection of avian reovirus contamination in avian viral vaccines. J Virol Methods 2005; 123:179–186 [View Article] [PubMed]
     [Google Scholar]
  10. Tang Y, Lu H. Whole genome alignment based one-step real-time RT-PCR for universal detection of avian orthoreoviruses of chicken, pheasant and turkey origins. Infect Genet Evol 2016; 39:120–126 [View Article] [PubMed]
     [Google Scholar]
  11. Sellers HS. Avian reoviruses from clinical cases of tenosynovitis: an overview of diagnostic approaches and 10-year review of isolations and genetic characterization. Avian Dis 2022; 66:420–426 [View Article] [PubMed]
     [Google Scholar]
  12. Kant A, Balk F, Born L, van Roozelaar D, Heijmans J et al. Classification of dutch and German avian reoviruses by sequencing the sigma C protein. Vet Res 2003; 34:203–212 [View Article] [PubMed]
     [Google Scholar]
  13. (OIE) WO for AH Manual of Diagnostic Tests and Vaccines for Terrestrial Animals (Terrestrial Manual)
     [Google Scholar]
  14. Roessler DE, Rosenberger JK. In vitro and in vivo characterization of avian reoviruses. III. Host factors affecting virulence and persistence. Avian Dis 1989; 33:555–565 [PubMed]
     [Google Scholar]
  15. al Afaleq AI, Jones RC. Localisation of avian reovirus in the hock joints of chicks after entry through broken skin. Res Vet Sci 1990; 48:381–382 [PubMed]
     [Google Scholar]
  16. Menendez NA, Calnek BW, Cowen BS. Experimental egg-transmission of avian reovirus. Avian Dis 1975; 19:104–111 [PubMed]
     [Google Scholar]
  17. Benavente J, Martinez-Costas J. Early steps in avian Reovirus Morphogenesis. Reoviruses Entry, Assem Morphog 200667–85
     [Google Scholar]
  18. Salsman J, Top D, Boutilier J, Duncan R. Extensive syncytium formation mediated by the reovirus FAST proteins triggers apoptosis-induced membrane instability. J Virol 2005; 79:8090–8100 [View Article] [PubMed]
     [Google Scholar]
  19. Chen X, He Z, Fu M, Wang Y, Wu H et al. The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation. J Virol 2018; 92:e02101-17 [View Article] [PubMed]
     [Google Scholar]
  20. Martínez-Costas J, González-López C, Vakharia VN, Benavente J. Possible involvement of the double-stranded RNA-binding core protein sigmaA in the resistance of avian reovirus to interferon. J Virol 2000; 74:1124–1131 [View Article] [PubMed]
     [Google Scholar]
  21. González-López C, Martínez-Costas J, Esteban M, Benavente J. Evidence that avian reovirus sigmaA protein is an inhibitor of the double-stranded RNA-dependent protein kinase. J Gen Virol 2003; 84:1629–1639 [View Article] [PubMed]
     [Google Scholar]
  22. Gao L, Liu R, Luo D, Li K, Qi X et al. Avian reovirus σA protein inhibits type I interferon production by abrogating interferon regulatory factor 7 activation. J Virol 2023; 97:e0178522 [View Article] [PubMed]
     [Google Scholar]
  23. Palomino-Tapia V, Mitevski D, Inglis T, van der Meer F, Abdul-Careem MF. Molecular characterization of emerging avian reovirus variants isolated from viral arthritis cases in Western Canada 2012-2017 based on partial sigma (σ)C gene. Virology 2018; 522:138–146 [View Article] [PubMed]
     [Google Scholar]
  24. Ayalew LE, Gupta A, Fricke J, Ahmed KA, Popowich S et al. Phenotypic, genotypic and antigenic characterization of emerging avian reoviruses isolated from clinical cases of arthritis in broilers in Saskatchewan, Canada. Sci Rep 2017; 7:3565 [View Article] [PubMed]
     [Google Scholar]
  25. Egaña-Labrin S, Hauck R, Figueroa A, Stoute S, Shivaprasad HL et al. Genotypic characterization of emerging avian reovirus genetic variants in California. Sci Rep 2019; 9:9351 [View Article] [PubMed]
     [Google Scholar]
  26. Lu H, Tang Y, Dunn PA, Wallner-Pendleton EA, Lin L et al. Isolation and molecular characterization of newly emerging avian reovirus variants and novel strains in Pennsylvania, USA, 2011–2014. Sci Rep 2015; 5: [View Article] [PubMed]
     [Google Scholar]
  27. Egaña-Labrin S, Jerry C, Roh HJ, da Silva AP, Corsiglia C et al. Avian reoviruses of the same genotype induce different pathology in chickens. Avian Dis 2021; 65:529–539 [View Article] [PubMed]
     [Google Scholar]
  28. Wickramasinghe R, Meanger J, Enriquez CE, Wilcox GE. Avian reovirus proteins associated with neutralization of virus infectivity. Virology 1993; 194:688–696 [View Article] [PubMed]
     [Google Scholar]
  29. Yin C, Qin L, Sun M, Gao Y, Qi X et al. Antigenic analysis of monoclonal antibodies against different epitopes of σB protein of avian reovirus. PLoS One 2013; 8:e81533 [View Article] [PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.001761
Loading
Avian reovirus: a furious and fast evolving pathogen
J. Med. Microbiol. 72, 001761 (2023); https://doi.org/10.1099/jmm.0.001761
/content/journal/jmm/10.1099/jmm.0.001761
/content/journal/jmm/10.1099/jmm.0.001761
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error