Abstract
Today cord blood (CB) is a valuable source of hematopoietic stem cells to treat many hematological disorders. One of the limitations of CB utilization is the reduced number of nucleated cells including stem cells. Therefore, CB banks around the world have developed strategies in an attempt to improve donor selection and the quality of the CB inventory. This study aimed to determine the impact of passive smoking and caffeine consumption on CB quality. CBs were obtained from mothers who gave birth at King Abdulaziz Medical City. All mothers gave their informed consent. Personal interviews about the mother's demographics, smoking status and exposure, and caffeine consumption executed, followed by a chart review to analyze maternal and neonatal factors. Laboratory testing was performed on all collected CB units. Using descriptive statistics, maternal and newborn factors were analyzed. T-test or Mann–Whitney U Test, as appropriate, for continuous variables analysis to study the effect of second hand smoking and coffee consumption for the primary outcome. Our study demonstrated a reduction in CB MNC, including lymphocytes, in caffeine consumers among pregnant donors, as well as a reduction in cell potency activities, including total CFU and BFU-E. The effect of passive cigarette smoking on the same cohort was insignificant. Outcome of this study will help in optimizing the quality and quantity of stem cell harvesting from CB to get the maximum benefit and such knowledge will raise the awareness among pregnant women.
Similar content being viewed by others
Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on request.
References
21 CFR 182.1180 – Caffeine (2013) https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?FR=182.1180. Accessed 15–16 Aug 2013
Al-Qahtani R, Al-Hedythi S, Arab S, Aljuhani A, Jawdat D (2016) Factor predicting total nucleated cell counts in cord blood units. Transfusion 56(9):2352–2354. https://doi.org/10.1111/trf.13707
Al-Sweedan SA, Musalam L, Obeidat B (2013) Factors predicting the hematopoietic stem cells content of the umbilical cord blood. Transfus Apher Sci 48:247–252
Askari S, Miller J, Moran S, Mccullough J (2002) Impact of donor and collection-related variables on product quality in cord blood banking. Transfusion 42:1S
Ballen K (2017) Update on umbilical cord blood transplantation. F1000Res 2017(6):1556. https://doi.org/10.12688/f1000research.11952.1
Ballen K (2017) Umbilical cord blood transplantation: challenges and future directions. Stem Cells Transl Med 6:1312–1315
Ballen K, Wilson M, Wuu J, Ceredona A, Hsieh C, Stewart F et al (2001) Bigger is better: maternal and neonatal predictors of hematopoietic potential of umbilical cord blood units. Bone Marrow Transpl 27(1):7
Bayraktar UD, de Lima M, Ciurea SO (2011) Advances in haploidentical stem cell transplantation. Rev Bras Hematol Hemoter 33(3):237–241. https://doi.org/10.5581/1516-8484.20110060
Broxmeyer H, Milano F (2021) Cord blood transplantation: state of the science. In: CBA Website, 2021. State of the Science (cb-association.org)
Broxmeyer HE, Douglas GW, Hangoc G et al (1989) Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A 86(10):3828–3832. https://doi.org/10.1073/pnas.86.10.3828
Danby R, Rocha V (2015) Clinical use of umbilical cord blood cells. In: Cord blood stem cells and regenerative medicine, chapter 7, pp 77–100
Dessels C, Alessandrini M, Pepper M (2018) Factors influencing the umbilical cord blood stem cell industry: an evolving treatment landscape. Stem Cells Transl Med 7(9):643–650. https://doi.org/10.1002/sctm.17-0244
Gupta AO, Wagner JE (2020) Umbilical Cord Blood Transplants: Current Status and Evolving Therapies. Front Pediatr. https://doi.org/10.3389/fped.2020.570282
Jan RH, Wen SH, Shyr MH, Chiang BL (2008) Impact of maternal and neonatal factors on CD34+ cell count, total nucleated cells, and volume of cord blood. Pediatr Transpl 12(8):868–873
Kurtzberg J (2017) A history of cord blood banking and transplantation. Stem Cell Transl Med 6:1309–1311. https://doi.org/10.1002/sctm.17-0075
Little A-M, Akbarzad-Yousefi A, Anand A, Burlinson ND, Dunn PPJ, Evseeva I, Latham K, Poulton K, Railton D, Vivers S, Wright PA (2021) BSHI guideline: HLA matching and donor selection for haematopoietic progenitor cell transplantation. Int J Immunogenet 48:75–109. https://doi.org/10.1111/iji.12527
Ma L, Han X, Jiang S, Meng Q, Zhang L, Bao H (2020) Haploidentical stem cell transplantation vs matched unrelated donor transplantation in adults with hematologic malignancies: a systematic review and meta-analysis. Hematology 25(1):356–365. https://doi.org/10.1080/16078454.2020.1831292
Mercelina-Roumans P, Breukers R, Ubachs J, Van Wersch J (1996) Hematological variables in cord blood of neonates of smoking and nonsmoking mothers. J Clin Epidemiol 49(4):449–454
Nakagawa R, Watanabe T, Kawano Y, Kanai S, Suzuya H, Kaneko M et al (2004) Analysis of maternal and neonatal factors that influence the nucleated and CD34+ cell yield for cord blood banking. Transfusion 44(2):262–267
Page KM, Mendizabal A, Betz-Stablein B et al (2014) Optimizing donor selection for public cord blood banking: influence of maternal, infant, and collection characteristics on cord blood unit quality. Transfusion 54:340–352
Passweg JR, Baldomero H, Bader P, Bonini C, Duarte RF, Dufour C, Gennery A, Kröger N, Kuball J, Lanza F, Montoto S, Nagler A, Snowden JA, Styczynski J, Mohty M, European Society for Blood and Marrow Transplantation (EBMT) (2017) Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transpl 52:811–817
Shlebak A, Roberts I, Stevens T, Szydlo R, Goldman J, Gordon M (1998) The impact of antenatal and perinatal variables on cord blood haemopoietic stem/progenitor cell yield available for transplantation. Br J Haematol 103:1167–1171
Thilaganathan B, Nicolaides KH, Morgan G (1994) Subpopulations of CD34-positive haemopoietic progenitors in fetal blood. Br J Haematol 87(3):634–636
Wyrsch A, Dalle Carbonare V, Jansen W, Chklovskaia E, Nissen C, Surbek D et al (1999) Umbilical cord blood from preterm human fetuses is rich in committed and primitive hematopoietic progenitors with high proliferative and self-renewal capacity. Exp Hematol 27(8):1338–45
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that there is no conflict of interest regarding the publication of this article.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Almashaqbeh, W., Ardah, H., Alasmari, A. et al. The effect of caffeine intake and passive smoking on umbilical cord blood unit’s quality parameters. Cell Tissue Bank (2023). https://doi.org/10.1007/s10561-023-10111-2
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10561-023-10111-2