An in vitro analog of learning that food is inedible in Aplysia: decreased responses to a transmitter signaling food after pairing with transmitters signaling failed swallowing
- 1Gonda (Goldschmied) Brain Research Center, Goodman Faculty of Life Science, Bar Ilan University, Ramat Gan 52900, Israel
- 2State Key Laboratory of Pharmaceutical Biotechnology, Institute for Brain Sciences, School Life Sciences, Nanjing University, Jiangsu 210023, China
- Corresponding author: avy{at}biu.ac.il
Abstract
An in vitro analog of learning that a food is inedible provided insight into mechanisms underlying the learning. Aplysia learn to stop responding to a food when they attempt but fail to swallow it. Pairing a cholinergic agonist with an NO donor or histamine in the Aplysia cerebral ganglion produced significant decreases in fictive feeding in response to the cholinergic agonist alone. Acetylcholine (ACh) is the transmitter of chemoreceptors sensing food touching the lips. Nitric oxide (NO) and histamine (HA) signal failed attempts to swallow food. Reduced responses to the cholinergic agonist after pairing with NO or HA indicate that learning partially arises via a decreased response to ACh in the cerebral ganglion.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.053867.123.
- Received August 9, 2023.
- Accepted September 13, 2023.
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