Uncovering the Biological Applications of Cinnamic Acid Derivatives: A
Patent Review

Ricardo   Silva   Porto; Viviane   Amaral   Porto

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Abstract

Background: Cinnamic acid, derived from Cinnamomum cassia, is a natural compound known for its wide-ranging therapeutic properties and minimal toxicity. Extensive research has demonstrated the diverse biological activities displayed by cinnamic acid derivatives, encompassing their potential as agents against cancer, diabetes, microbial infections, tuberculosis, malaria, and more.

Objective: This review aims to provide an overview of the latest applications detailing the biological activity of cinnamic acid derivatives, as documented in patents.

Methods: The published patent data underwent a prior screening and selection process based on their relevance and primary focus: the biological activities of cinnamic acid derivatives as potential drugs. Espacenet, USPTO, and Google Patents were used for this selection.

Results: Cinnamic acid derivatives demonstrate a range of activities, including anticancer, antibacterial, anti-inflammatory, analgesic, anticholinesterase, and other properties. These biological activities were investigated across different derivatives, emphasizing their pharmacological potential when compared to reference compounds.

Conclusions: Despite several patents have explored the biological properties of cinnamic acid derivatives, there has been a lack of a comprehensive review dedicated to this subject. Accordingly, this review aims to facilitate the discovery of new and diverse potential drugs with various therapeutic profiles.

Keywords: Cinnamic acid, biological activities, patent, anticancer, antibacterial

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DOI https://dx.doi.org/10.2174/0115701808273623231009074241	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

Letters in Drug Design & Discovery

Uncovering the Biological Applications of Cinnamic Acid Derivatives: A Patent Review

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