Abstract
Ti6Al4V3Cu alloy is a promising biomaterial for combating implant-related infection. However, the antibacterial property of Ti6Al4V3Cu is expected to be enhanced due to the low content of Cu element in titanium. To address this issue, the antibacterial property of Ti6Al4V3Cu was tailored by the grooves with different groove widths (30 μm, 60 μm, and 90 μm) that were constructed on the surface of the Ti6Al4V3Cu by selective laser melting. The effect of grooves on corrosion resistance, antibacterial property, and cytocompatibility was investigated. The electrochemical tests showed that the corrosion resistance decreased with increasing groove width. The antibacterial tests indicated that the groove with a width of 30 μm and 90 μm groups showed better antibacterial activity against S. aureus (> 90%) compared with the groove with a width of 60 μm. The in vitro study suggested that all samples with different grooves were found to exhibit good cytocompatibility with osteoblast cells. It is considered that creating grooves on Ti6Al4V3Cu by selective laser melting is a promising strategy to enhance the antibacterial activity without sacrificing cytocompatibility.
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References
J.Y. Lee, J. An, C.K. Chua, Appl. Mater. Today 7, 120 (2017)
L.Y. Chen, Y.W. Cui, L.C. Zhang, Metals-Basel 10, 1139 (2020)
C. Sun, Y. Wang, M.D. McMurtrey, N.D. Jerred, F. Liou, J. Li, Appl. Energ. 282, 116041 (2021)
N. Dai, L.C. Zhang, J. Zhang, X. Zhang, Q. Ni, Y. Chen, M. Wu, C. Yang, Corros. Sci. 111, 703 (2016)
P. Qin, L.Y. Chen, Y.J. Liu, C.H. Zhao, Y.J. Lu, H. Sun, L.C. Zhang, Corros. Sci. 213, 110999 (2023)
Y. Lu, X. Liu, Y. Liu, X. Wu, Y. Jiang, Z. Liu, J. Lin, L. Zhang, Compos. Pt. A-Appl. S. 164, 107278 (2023)
M. Fischer, D. Joguet, G. Robin, L. Peltier, P. Laheurte, Mat. Sci. Eng. C-Mater. 62, 852 (2016)
X. Liu, P. Chu, C. Ding, Mat. Sci. Eng. R 47, 49 (2004)
M. Geetha, A.K. Singh, R. Asokamani, A.K. Gogia, Prog. Mater. Sci. 54, 397 (2009)
M. Long, H. Rack, Biomaterials 19, 1621 (1998)
M. Niinomi, Mat. Sci. Eng. A-Struct. 243, 231 (1998)
K. Banaszek, L. Klimek, E. Zgorzynska, A. Swarzynska, A. Walczewska, Biomed. Mater. 13, 045003 (2018)
S. Qin, X. Xu, Y. Lu, L. Li, T. Huang, J. Lin, Acta Metall. Sin. -Engl. Lett. 35, 812 (2022)
R. Trindade, T. Albrektsson, S. Galli, Z. Prgomet, P. Tengvall, A. Wennerberg, Clin. Implant Dent. Relat. Res. 20, 82 (2018)
H. Chouirfa, H. Bouloussa, V. Migonney, C. Falentin-Daudre, Acta Biomater. 83, 37 (2019)
J. Josse, F. Valour, Y. Maali, A. Diot, C. Batailler, T. Ferry, F. Laurent, Front. Microbiol. 10, 1602 (2019)
J.A. Koch, T.M. Pust, A.J. Cappellini, J.B. Mandell, D. Ma, N.B. Shah, K.M. Brothers, K.L. Urish, Life-Basel 10, 253 (2020)
W.F. Oliveira, P.M.S. Silva, R.C.S. Silva, G.M.M. Silva, G. Machado, L. Coelho, M.T.S. Correia, J. Hosp. Infect. 98, 111 (2018)
M. Kaur, K. Singh, Mat. Sci. Eng. C. -Mater. 102, 844 (2019)
J.M. Anderson, Regen. Biomater. 3, 73 (2016)
C.R. Arciola, D. Campoccia, L. Montanaro, Nat. Rev. Microbiol. 16, 397 (2018)
A.L. Overmann, C. Aparicio, J.T. Richards, I. Mutreja, N.G. Fischer, S.M. Wade, B.K. Potter, T.A. Davis, J.E. Bechtold, J.A. Forsberg, D. Dey, J. Orthop. Res. 38, 1445 (2020)
A.G. Gristina, Science 237, 1588 (1987)
R. Liu, K. Memarzadeh, B. Chang, Y. Zhang, Z. Ma, R.P. Allaker, L. Ren, K. Yang, Sci. Rep.-UK 6, 29985 (2016)
S. Cadiou, M. Bustamante, L. Agier, S. Andrusaityte, X. Basagana, Environ. Int. 138, 105622 (2020)
T.Y. Klein, J. Wehling, L. Treccani, K. Rezwan, Environ. Sci. Technol. 47, 1065 (2013)
E. Zhang, F. Li, H. Wang, J. Liu, C. Wang, M. Li, K. Yang, Mat. Sci. Eng. C. -Mater. 33, 4280 (2013)
L. Ren, Z. Ma, M. Li, Y. Zhang, W. Liu, Z. Liao, K. Yang, J. Mater. Sci. Technol. 30, 699 (2014)
J. Zhang, L. Ren, K. Yang, Acta Metall. Sin. -Engl. Lett. 34, 694 (2021)
T. Shirai, H. Tsuchiya, T. Shimizu, K. Ohtani, Y. Zen, K. Tomita, J. Biomed. Mater. Res. B 91, 373 (2009)
C. Xin, N. Wang, Y. Chen, B. He, Q. Zhao, L. Chen, Y. Tang, B. Luo, Y. Zhao, X. Yang, Mater. Des. 215, 110540 (2022)
J. Liu, F. Li, C. Liu, H. Wang, B. Ren, K. Yang, E. Zhang, Mat. Sci. Eng. C -Mater. 35, 392 (2014)
Y. Xu, J. Jiang, Z. Yang, Q. Zhao, Y. Chen, Y. Zhao, Mater. Basel 13, 3411 (2020)
Y. Xie, M. Lu, S. Cui, H. Yu, L. Wang, H. Ke, E. Zhang, Metals-Basel 12, 1008 (2022)
S. Kligman, Z. Ren, C.H. Chung, M.A. Perillo, Y.C. Chang, H. Koo, Z. Zheng, C. Li, J. Clin. Med. 10, 1641 (2021)
W. Teughels, N. Van Assche, I. Sliepen, M. Quirynen, Clin. Oral Implan. Res. 17, 68 (2006)
R.C. Petersen, P.R. Liu, M.S. Reddy, E.C. Dent, EC Dent. Sci. 19, 1 (2020)
W. Soboyejo, B. Nemetski, S. Allameh, N. Marcantonio, C. Mercer, J. Ricci, J. Biomed. Mater. Res. 62, 56 (2002)
J.L. Ricci, H. Alexander, Key Eng. Mater. 198–199, 179 (2001)
O. Raimbault, S. Benayoun, K. Anselme, C. Mauclair, T. Bourgade, A.M. Kietzig, P.L. Girard-Lauriault, S. Valette, C. Donnet, Mat. Sci. Eng. C -Mater. 69, 311 (2016)
J. Chen, J.P. Ulerich, E. Abelev, A. Fasasi, C.B. Arnold, W.O. Soboyejo, Mat. Sci. Eng. C -Mater. 29, 1442 (2009)
Y.W. Cui, L.Y. Chen, Y.H. Chu, L. Zhang, R. Li, S. Lu, L. Wang, L.C. Zhang, Corros. Sci. 215, 111017 (2023)
L. Li, Y. Chen, Y. Lu, S. Qin, G. Huang, T. Huang, J. Lin, J. Mater. Res. Technol. 12, 904 (2021)
X. Wu, H. Ma, S. Chen, Z. Xu, A. Sui, J. Electrochem. Soc. 146, 1847 (1999)
J.B. Jorcin, M.E. Orazem, N. Pébère, B. Tribollet, Electrochim. Acta 51, 1473 (2006)
J. Li, X. Liu, G. Li, P. Han, W. Liang, Metals-Basel 7, 138 (2017)
M. Łępicka, A. Ciszewski, K. Golak, M. Grądzka-Dahlke, Materials 12, 4163 (2019)
J. Zhu, G. Zhang, G. Xian, N. Zhang, J. Li, Front. Chem. 7, 796 (2019)
Y. Ma, J. Yan, T. Yan, Q. Wang, Z. Bao, Z. Yi, Front. Mater. 9, 999794 (2022)
G.M. Sena, S. Sivan, J.D. Weaver, M. Di Prima, NPJ Mat. Degrad. 4, 23 (2020)
G.F. Kennell, R.W. Evitts, K.L. Heppner, Corros. Sci. 50, 1716 (2008)
A. Betts, L. Boulton, Br. Corros. J. 28, 279 (1993)
Y.W. Cui, L.Y. Chen, P. Qin, R. Li, Q. Zang, J. Peng, L. Zhang, S. Lu, L. Wang, L.C. Zhang, Corros. Sci. 203, 110333 (2022)
S. Popov, O. Saphier, M. Popov, M. Shenker, S. Entus, Y. Shotland, M. Saphier, Curr. Microbiol. 77, 361 (2020)
M. Saphier, E. Silberstein, Y. Shotland, S. Popov, O. Saphier, Curr. Microbiol. 75, 426 (2018)
Z. Zhang, X.R. Zhang, T. Jin, C.G. Yang, Y.P. Sun, Q. Li, K. Yang, Rare Met. 41, 559 (2022)
S.L. Warnes, C.W. Keevil, Appl. Environ. Microbiol. 77, 6049 (2011)
C.M. Bollenl, P. Lambrechts, M. Quirynen, Dent. Mater. 13, 258 (1997)
H. Liu, R. Liu, I. Ullah, S. Zhang, Z. Sun, L. Ren, K. Yang, J. Mater. Sci. Technol. 48, 130 (2020)
K.T. Bowers, J.C. Keller, B.A. Randolph, D.G. Wick, C.M. Michaels, Int. J. Oral. Max. Impl. 2, 131 (1993)
T. Wang, Y. Wan, Z. Kou, Y. Cai, B. Wang, Z. Liu, P. I. Mech. Eng. H. 230, 1086 (2016)
H. Liao, A.-S. Andersson, D. Sutherland, S. Petronis, B. Kasemo, P. Thomsen, Biomaterials 24, 649 (2003)
R. Huang, L. Zhang, L. Huang, J. Zhu, Mat. Sci. Eng. C -Mater. 97, 688 (2019)
Q. Zheng, L. Mao, Y. Shi, W. Fu, Y. Hu, Mater. Technol. 37, 2039 (2020)
C. Michaels, J. Dent. Res. 68, 276 (1989)
A.W. Robert, B.H. Marcon, B. Dallagiovanna, P. Shigunov, Front. Cell Dev. Biol. 8, 561 (2020)
J. Martin, Z. Schwartz, T. Hummert, D. Schraub, J. Simpson, J. Lankford Jr., D. Dean, D. Cochran, B.D. Boyan, J. Biomed. Mater. Res. 29, 389 (1995)
Acknowledgements
The design of the study and collection, analysis, and interpretation of data were supported by the National Natural Science Foundation of China (No. 51801198), the Funds of Scientific and Technological Plan of Fujian Province (Nos. 2020Y9064, 2020Y0083 and 2020L3026) and Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China (No. 2021ZZ111).
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Zhou, M., Sun, H., Gan, Y. et al. Tuning the Corrosion Resistance, Antibacterial Activity, and Cytocompatibility by Constructing Grooves on the Surface of Ti6Al4V3Cu Alloy. Acta Metall. Sin. (Engl. Lett.) 36, 1979–1998 (2023). https://doi.org/10.1007/s40195-023-01620-w
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DOI: https://doi.org/10.1007/s40195-023-01620-w