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Osteopontin: an essential regulatory protein in idiopathic pulmonary fibrosis

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Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic lung disease characterized by abnormal proliferation and activation of fibroblasts, excessive accumulation of extracellular matrix (ECM), inflammatory damage, and disrupted alveolar structure. Despite its increasing morbidity and mortality rates, effective clinical treatments for IPF remain elusive. Osteopontin (OPN), a multifunctional ECM protein found in various tissues, has been implicated in numerous biological processes such as bone remodeling, innate immunity, acute and chronic inflammation, and cancer. Recent studies have highlighted the pivotal role of OPN in the pathogenesis of IPF. This review aims to delve into the involvement of OPN in the inflammatory response, ECM deposition, and epithelial-mesenchymal transition (EMT) during IPF, and intends to lay a solid theoretical groundwork for the development of therapeutic strategies for IPF.

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Acknowledgements

This work was supported by the Key Research and Development Program of Jiangsu Province of China (BE2021707).

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  1. Xiaoyu Zhu and Jie Ji these authors contributed equally to this work.

Authors and Affiliations

  1. Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Hankou Road 22, Nanjing, 210093, China

    Xiaoyu Zhu, Jie Ji & Xiaodong Han

  2. Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China

    Xiaoyu Zhu, Jie Ji & Xiaodong Han

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  1. Xiaoyu Zhu
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Xiaoyu Zhu: Conceptualization, Data curation, Formal analysis, Methodology, Software, Writing original draft. Ji Jie: Conceptualization, Software, Visualization, Writing original draft. Xiaodong Han: Conceptualization, Formal analysis, Methodology, Funding acquisition.

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Correspondence to Xiaodong Han.

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Zhu, X., Ji, J. & Han, X. Osteopontin: an essential regulatory protein in idiopathic pulmonary fibrosis. J Mol Histol 55, 1–13 (2024). https://doi.org/10.1007/s10735-023-10169-y

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