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New binuclear Cu (II) complex: synthesis, structural elucidation, cytotoxic and DNA-binding evaluation

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Abstract

A novel copper complex [Cu(μ2–OH)(1,10-phenanthroline)(4-aminobenzenesulfonic acid)·3H2O]2 (1) was synthesized and characterized by X-ray single-crystal diffraction, elemental analysis and IR spectroscopy. X-ray crystallography of complex 1 showed strictly planar bridged μ2–Cu2(OH)2 core where copper (II) center exhibited a distorted square pyramidal coordination geometry. The interaction of the complex with calf thymus DNA (CT DNA) was investigated by absorption titration and viscosity measurement. The results revealed an intercalation binding between DNA and complex 1 with a binding strength of 6.0731 × 106 ± 0.0032 M−1. The antitumor capacity of the complex was tested in vitro against human colorectal (HCT 116) cancer cell lines by metabolic tests, using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide reagent. Complex 1 showed remarkably low IC50 values of 4.844 ± 0.025 μM compared to 5-fluorouracil (7.3 μM), a widely used clinical antitumor drug.

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Authors and Affiliations

  1. Department of Chemistry, College of Science, University of Basrah, Basrah, 6100, Iraq

    Mouayed A. Hussein & Adyan A. Yaseen

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  1. Mouayed A. Hussein
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Adyan A. Yaseen conducted the experiments under the supervision of Mouayed A. Hussein. The authors have equal contribution to this work. Mouayed A. Hussein wrote the main manuscript, and Adyan A. Yaseen prepared the tables and figures.

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Correspondence to Mouayed A. Hussein.

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Hussein, M.A., Yaseen, A.A. New binuclear Cu (II) complex: synthesis, structural elucidation, cytotoxic and DNA-binding evaluation. Transit Met Chem 49, 53–62 (2024). https://doi.org/10.1007/s11243-023-00561-8

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