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Accelerated wound healing with resveratrol‐loaded decellularized pericardium in mice model

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Abstract

One of the key objectives of regenerative medicine is the design of skin tissue engineering scaffolds to promote wound healing. These scaffolds provide a fresh viewpoint on skin injury repair by emulating body tissues in their structure. A suitable platform for cellular processes can be provided by natural scaffolds made from decellularized tissues while retaining the primary components. Resveratrol (RES), which has qualities like angiogenesis, antioxidant, antibacterial, and anti-inflammatory, is also useful in the healing of wounds. In this investigation, RES-loaded decellularized sheep pericardium scaffolds were created and tested on full-thickness wounds in a mouse model. According to the in vivo findings, the groups in which the wound was treated with decellularized pericardium (DP) had better wound healing than the control group and showed more production of angiogenic and anti-inflammatory substances. The secretion of these factors was greater in RES‐loaded decellularized pericardium (DP-RES) than in the scaffold without RES, and the macroscopic and histological data supported this. Therefore, the use of decellularization scaffolds with substances like RES for the regeneration of skin wounds can be further researched and evaluated in the preclinical stages.

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Data availability

The datasets generated during and/or analyzed in this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors would like to thank the Fertility and Infertility Research Center.

Funding

This paper was funded research deputy of Kermanshah University of Medical Sciences, Kermanshah, Iran.

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Authors and Affiliations

  1. Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mozafar Khazaei, Mohammad Rasool Khazaei & Leila Rezakhani

  2. Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mozafar Khazaei, Mohammad Rasool Khazaei & Leila Rezakhani

  3. Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

    Shima Rahmati

Authors
  1. Mozafar Khazaei
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  2. Shima Rahmati
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  3. Mohammad Rasool Khazaei
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  4. Leila Rezakhani
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Contributions

MK performed data measurement and statistical analysis. SR, MRK, LR performed the dissection experiments and wrote the first draft of the manuscript. MK. LR contributed to the conception and design of the study. All authors contributed to the manuscript revision, read, and approved the submitted version.

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Correspondence to Leila Rezakhani.

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Conflict of interest

No potential conflict of interest was reported by the authors.

Ethical approval

This study was accepted under the management of the Ethics Committee of Kermanshah University of Medical Sciences and with the ethics code IR.KUMS.AEC.1400.006.

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Khazaei, M., Rahmati, S., Khazaei, M.R. et al. Accelerated wound healing with resveratrol‐loaded decellularized pericardium in mice model. Cell Tissue Bank 25, 245–253 (2024). https://doi.org/10.1007/s10561-023-10117-w

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  • DOI: https://doi.org/10.1007/s10561-023-10117-w

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