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Abstract
Tubercidin is an adenosine analogue that has been shown to exhibit good activity against some tumours and parasites. In this study, the in vitro activity of tubercidin was evaluated against Mycobacterium tuberculosis (Mtb) and nontuberculosis Mycobacteria (NTM). For determining the MICs of tubercidin, 23 fully drug-sensitive (DS) Mtb strains, 33 multi-drug resistance tuberculosis (MDR-TB) strains, 29 pre-extensively drug-resistant tuberculosis (pre-XDR-TB) strains, 21 extensively drug-resistant tuberculosis (XDR-TB) strains, 17 rapidly growing mycobacteria (RGM) and nine slowly growing mycobacteria (SGM) references strains were tested by microplate-based Alamar Blue assay (MABA) method. The results indicate that tubercidin has high in vitro activity against some drug-resistance Mtb strains and NTM reference strains, which warrants further investigation on the actions of tubercidin and its derivatives as potential drugs for mycobacterial infections.
- Received:
- Accepted:
- Published Online:
Funding
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Tongzhou Yunhe Project under Grant
(Award YH201917)
- Principle Award Recipient: GuirongWang
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Beijing Public Health Experts Project
(Award 2022-3-040)
- Principle Award Recipient: GuirongWang
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2115 Talent Development Program of China Agricultural University
(Award 00109029)
- Principle Award Recipient: HaoLi
-
National Natural Science Foundation of China
(Award 32070937)
- Principle Award Recipient: HaoLi
-
National Natural Science Foundation of China
(Award 81703632)
- Principle Award Recipient: GuirongWang
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National Key Research and Development Program of China
(Award 2021YFD1800400)
- Principle Award Recipient: HaoLi