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Astrocytic transcriptional and epigenetic mechanisms of drug addiction

  • Psychiatry and Preclinical Psychiatric Studies - Review Article
  • Published:
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Abstract

Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are thought to underlie behavioral adaptations. Emerging evidence implicates astrocytes in regulating drug-seeking behaviors and demonstrates robust transcriptional response to several substances of abuse. This review focuses on the astrocytic transcriptional and epigenetic mechanisms of drug action.

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Acknowledgements

The research of the authors of this manuscript were supported by NIH P01DA047233 (EJN) and T32DA053558 (LMH). Figures were generated with Biorender.

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Authors and Affiliations

  1. Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Leanne M. Holt & Eric J. Nestler

  2. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Leanne M. Holt & Eric J. Nestler

  3. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Eric J. Nestler

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  1. Leanne M. Holt
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Holt, L.M., Nestler, E.J. Astrocytic transcriptional and epigenetic mechanisms of drug addiction. J Neural Transm 131, 409–424 (2024). https://doi.org/10.1007/s00702-023-02716-4

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