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Nociceptors and Macrophages in Bacterial Meningitis: Partners in Crime?

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Fig. 1

Pinho-Ribeiro et al. [4] demonstrated that bacteria directly activate TRPV1+ nociceptors in the meninges, leading to the release of CGRP. This neuropeptide suppresses chemokine expression in meningeal macrophages through CGRP-RAMP1 signaling, thereby dampening the host defense and promoting bacterial meningitis. On the other hand, Zhang et al. [7] showed that TRPV1+ nociceptors release substance P (SP) to regulate the intestinal microbiota in a mouse model of colitis induced by DSS. This regulation helps protect the barrier tissue from inflammation

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Authors and Affiliations

  1. The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai,, New York, NY10029, USA

    Fang Gao & Hongzhen Hu

  2. The Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY10029, USA

    Hongzhen Hu

  3. The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY10029, USA

    Hongzhen Hu

  4. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY10029, USA

    Hongzhen Hu

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  1. Fang Gao
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Correspondence to Fang Gao or Hongzhen Hu.

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Gao, F., Hu, H. Nociceptors and Macrophages in Bacterial Meningitis: Partners in Crime?. Neurosci. Bull. 40, 418–420 (2024). https://doi.org/10.1007/s12264-023-01141-7

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  • DOI: https://doi.org/10.1007/s12264-023-01141-7

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