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Review Article

Exploring the Cell Wall and Secretory Proteins of Mycobacterium leprae as Biomarkers

Author(s): Sakshi Singh, Devesh Sharma, Sakshi Gautam, Mamta Arora and Deepa Bisht*

Volume 31, Issue 1, 2024

Published on: 13 November, 2023

Page: [11 - 24] Pages: 14

DOI: 10.2174/0109298665267993231026114709

Price: $65

Abstract

The bacterial cell wall is composed of a wide variety of intricate proteins in addition to lipids, glycolipids, and polymers. Given the diversity of cell wall proteins among bacterial species, they are a feasible target for biomarker identification and characterization in clinical research and diagnosis of the disease. The slow growth rate of Mycobacterium leprae poses a major hurdle in the accurate diagnosis of leprosy before the onset of peripheral neuropathy. The use of biomarker- based diagnostic methods can help in preventing the spread and manifestation of leprosy. Despite many advances in research methods and techniques, there remains a knowledge gap regarding the cell wall proteomes of M. leprae that can be used as biomarkers. The cell wall and secretory proteins of M. leprae are the major focus of this review article. This article enfolds the characteristics and functions of M. leprae cell wall proteins and gives an insight into those cell wall proteins that are yet to be established as biomarkers. Tools and techniques used in cell wall extraction and biomarker identification can also be explored in this article.

Keywords: Cell wall proteins, secretory proteins, biomarkers, Mycobacterium leprae, leprosy, proteomics.

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Graphical Abstract

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