1887

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Volume 72, Issue 11

and its impact on human and animal tuberculosis Open Access

This article is part of the JMM Profiles collection.

Graphical Abstract

 Graphical abstract 

is a slow-growing (16–20 h generation time), Gram-positive and acid-fast bacterium member of the complex pathogen group (MTBC). They are characterized by a complex, protective cell wall containing mycolic acids. The MTBCs are the causative agents of tuberculosis (TB). Following initial infection, subsequent pathological changes, and the progress of infection depend on the interplay between host defence mechanisms and mycobacterial virulence factors and the balance between the immunologic protective responses and the damaging inflammatory processes. Progression of the disease is characterized by the formation of typical caseous tuberculous granuloma (inflammatory mononuclear cell aggregates) because of the host's immune response to infection. The transmission and epidemiology of are complex and vary depending on the situation and ecosystem. In the UK, the spread of BTB in the UK cattle herd can occur by transmitting the disease from cattle to cattle and between badgers but also between badgers and cattle. The disease is thought to be primarily a respiratory disease with spread between individuals through mechanisms such as coughing or transfer of bacteria in respiratory secretions. It is also thought that environmental contamination may also lead to some transmission. The protective cell wall of the organism is believed to allow the organism to survive outside an animal host, which can then transfer to new hosts following subsequent environmental exposure. In some situations, ingestion of pathogens in food can lead to infection. The relative contribution of these routes and precise transmission mechanisms needs to be better understood.

 

Abstract

belongs to the complex pathogen group (MTBC), which includes . These organisms cause tuberculosis (TB), a disease characterized by the formation of tubercles and caseous necrosis in the lungs. is the leading cause of bovine tuberculosis (bTB) in cattle and other domestic and wild animals. It also causes disease in humans (zoonotic TB). Other MTBC pathogens like or can also cause bTB. However, is the focus of this review. In addition to direct health consequences, bTB has a significant global economic impact in developed and developing countries.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): farming , surveillance , veterinary and zoonotic
© 2023 Crown Copyright
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-11-14
2024-04-27
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References

  1. Smith T. A comparative study of bovine tubercule bacilli and of human bacilli from sputum. J Exp Med 1898; 3:451–511 [View Article] [PubMed]
     [Google Scholar]
  2. Koch R. Die Aetiologie der Tuberkulose. Berl Klin Wochenschr 1882; 19:221–230
     [Google Scholar]
  3. Karlson AG, Lessel EF. Mycobacterium bovis nom. nov. Int J Syst Bacteriol 1970; 20:273–282 [View Article]
     [Google Scholar]
  4. Li J, Zhan L, Qin C. The double-sided effects of Mycobacterium Bovis bacillus Calmette-Guérin vaccine. NPJ Vaccines 2021; 6:14 [View Article] [PubMed]
     [Google Scholar]
  5. WOAH Terrestrial Manual 2022 Chapter 3 .1. 1 3 Mammalian Tuberculosis (Infection with mycobacterium tuberculosis complex); 2022 www.woah.org/en/home/bovine-tuberculosis accessed 1 September 2023
  6. Olea-Popelka F, Muwonge A, Perera A, Dean AS, Mumford E et al. Zoonotic tuberculosis in human beings caused by Mycobacterium bovis-a call for action. Lancet Infect Dis 2017; 17:e21–e25 [View Article] [PubMed]
     [Google Scholar]
  7. Global tuberculosis report 2022 ISBN 978-92-4-006172-9 (electronic version) ISBN 978-92-4-006173-6 (print version) © World Health Organization; 2022 www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022
  8. Garnier T, Eiglmeier K, Camus J-C, Medina N, Mansoor H et al. The complete genome sequence of Mycobacterium bovis. Proc Natl Acad Sci U S A 2003; 100:7877–7882 [View Article] [PubMed]
     [Google Scholar]
  9. Guimaraes AMS, Zimpel CK. Mycobacterium bovis: from genotyping to genome sequencing. Microorganisms 2020; 8:667 [View Article] [PubMed]
     [Google Scholar]
  10. Delogu G, Brennan MJ, Manganelli R. PE and PPE genes: a tale of conservation and diversity. Adv Exp Med Biol 2017; 1019:191–207 [View Article] [PubMed]
     [Google Scholar]
  11. Borham M, Oreiby A, El-Gedawy A, Hegazy Y, Khalifa HO et al. Review on bovine tuberculosis: an emerging disease associated with multidrug-resistant Mycobacterium species. Pathogens 2022; 11:715 [View Article] [PubMed]
     [Google Scholar]
  12. Srinivasan S, Jones G, Veerasami M, Steinbach S, Holder T et al. A defined antigen skin test for the diagnosis of bovine tuberculosis. Sci Adv 2019; 5:eaax4899 [View Article] [PubMed]
     [Google Scholar]
  13. Pai M, Denkinger CM, Kik SV, Rangaka MX, Zwerling A et al. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev 2014; 27:3–20 [View Article] [PubMed]
     [Google Scholar]
  14. McCallan L, Brooks C, Barry C, Couzens C, Young FJ et al. Serological test performance for bovine tuberculosis in cattle from herds with evidence of on-going infection in Northern Ireland. PLoS One 2021; 16:e0245655 [View Article] [PubMed]
     [Google Scholar]
  15. Corner LAL, Gormley E, Pfeiffer DU. Primary isolation of Mycobacterium bovis from bovine tissues: conditions for maximising the number of positive cultures. Vet Microbiol 2012; 156:162–171 [View Article] [PubMed]
     [Google Scholar]
  16. Zeka AN, Tasbakan S, Cavusoglu C. Evaluation of the GeneXpert MTB/RIF assay for rapid diagnosis of tuberculosis and detection of rifampin resistance in pulmonary and extrapulmonary specimens. J Clin Microbiol 2011; 49:4138–4141 [View Article] [PubMed]
     [Google Scholar]
  17. Lorente-Leal V, Liandris E, Pacciarini M, Botelho A, Kenny K et al. Direct PCR on tissue samples to detect Mycobacterium tuberculosis complex: an alternative to the bacteriological culture. J Clin Microbiol 2021; 59:e01404-20 [View Article] [PubMed]
     [Google Scholar]
  18. Jagielski T, van Ingen J, Rastogi N, Dziadek J, Mazur PK et al. Current methods in the molecular typing of Mycobacterium tuberculosis and other mycobacteria. Biomed Res Int 2014645802 [View Article] [PubMed]
     [Google Scholar]
  19. Guimaraes AMS, Zimpel CK. Mycobacterium bovis: from genotyping to genome sequencing. Microorganisms 2020; 8:667 [View Article] [PubMed]
     [Google Scholar]
  20. Lumb R, Shephard L, Bastian I, Fitz-Gerald M. Laboratory Safety. Tuberculosis Work Safe, Global Edition. 2019 ISBN: 978-0-6486845-1-0 (PDF) ISBN: 978-0-6486845-0-3
     [Google Scholar]
  21. Anon Tuberculosis Laboratory Biosafety Manual Essential biosafety measures for TB laboratories. Geneva: World Health Organization; 2012 https://www.ncbi.nlm.nih.gov/books/NBK179129/
  22. Lan Z, Bastos M, Menzies D. Treatment of human disease due to Mycobacterium bovis: a systematic review. Eur Respir J 2016; 48:1500–1503 [View Article] [PubMed]
     [Google Scholar]
  23. O’Reilly LM, Daborn CJ. The epidemiology of Mycobacterium bovis infections in animals and man: a review. Tuber Lung Dis 1995; 76:1–46 [View Article] [PubMed]
     [Google Scholar]
  24. Forrellad MA, Klepp LI, Gioffré A, Sabio y García J, Morbidoni HR et al. Virulence factors of the Mycobacterium tuberculosis complex. Virulence 2013; 4:3–66 [View Article] [PubMed]
     [Google Scholar]
  25. Domingo M, Vidal E, Marco A. Pathology of bovine tuberculosis. Res Vet Sci 2014; 97:S20–S29 [View Article] [PubMed]
     [Google Scholar]
  26. Gibson AJ, Stiens J, Passmore IJ, Faulkner V, Miculob J et al. Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic Mycobacteria. mBio 2022; 13:e0067222 [View Article] [PubMed]
     [Google Scholar]
  27. Kock R, Michel AL, Yeboah-Manu D, Azhar EI, Torrelles JB et al. Zoonotic tuberculosis - the changing landscape. Int J Infect Dis 2021; 113:S68–S72 [View Article] [PubMed]
     [Google Scholar]
  28. Taye H, Alemu K, Mihret A, Wood JLN, Shkedy Z et al. Global prevalence of Mycobacterium bovis infections among human tuberculosis cases: systematic review and meta-analysis. Zoonoses Public Health 2021; 68:704–718 [View Article] [PubMed]
     [Google Scholar]
  29. de la Rua-Domenech R. Human Mycobacterium bovis infection in the United Kingdom: incidence, risks, control measures and review of the zoonotic aspects of bovine tuberculosis. Tuberculosis 2006; 86:77–109 [View Article] [PubMed]
     [Google Scholar]
  30. Ramos B, Pereira AC, Reis AC, Cunha MV. Estimates of the global and continental burden of animal tuberculosis in key livestock species worldwide: a meta-analysis study. One Health 2020; 10:100169 [View Article] [PubMed]
     [Google Scholar]
  31. Thomas J, Balseiro A, Gortázar C, Risalde MA. Diagnosis of tuberculosis in wildlife: a systematic review. Vet Res 2021; 52:31 [View Article] [PubMed]
     [Google Scholar]
  32. Calmette A, Guérin C. Nouvelles recherches expérimentales sur La vaccination des Bovidés Contre La Tuberculose et sur le sort des Bacilles Tuberculeux Dans L’Organisme des Vaccinés. Ann Inst Pasteur 1913; 27:162–169
     [Google Scholar]
  33. Behr MA, Wilson MA, Gill WP, Salamon H, Schoolnik GK et al. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 1999; 284:1520–1523 [View Article] [PubMed]
     [Google Scholar]
  34. Ahmed A, Rakshit S, Adiga V, Dias M, Dwarkanath P et al. A century of BCG: impact on tuberculosis control and beyond. Immunol Rev 2021; 301:98–121 [View Article] [PubMed]
     [Google Scholar]
  35. Srinivasan S, Conlan AJK, Easterling LA, Herrera C, Dandapat P et al. A meta-analysis of the effect of Bacillus calmette-guérin vaccination against Bovine tuberculosis: is perfect the enemy of good?. Front Vet Sci 2021; 8:637580 [View Article] [PubMed]
     [Google Scholar]
  36. Milián-Suazo F, González-Ruiz S, Contreras-Magallanes YG, Sosa-Gallegos SL, Bárcenas-Reyes I et al. Vaccination strategies in a potential use of the vaccine against Bovine tuberculosis in infected herds. Animals 2022; 12:3377 [View Article] [PubMed]
     [Google Scholar]
  37. Srinivasan S, Subramanian S, Shankar Balakrishnan S, Ramaiyan Selvaraju K, Manomohan V et al. A defined antigen skin test that enables implementation of BCG vaccination for control of Bovine tuberculosis: proof of concept. Front Vet Sci 2020; 7:391 [View Article] [PubMed]
     [Google Scholar]
  38. Narasimhan P, Wood J, Macintyre CR, Mathai D. Risk factors for tuberculosis. Pulm Med 2013828939 [View Article] [PubMed]
     [Google Scholar]
  39. Broughan JM, Judge J, Ely E, Delahay RJ, Wilson G et al. A review of risk factors for bovine tuberculosis infection in cattle in the UK and Ireland. Epidemiol Infect 2016; 144:2899–2926 [View Article] [PubMed]
     [Google Scholar]
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Mycobacterium bovis and its impact on human and animal tuberculosis
J. Med. Microbiol. 72, 001769 (2023); https://doi.org/10.1099/jmm.0.001769
/content/journal/jmm/10.1099/jmm.0.001769
/content/journal/jmm/10.1099/jmm.0.001769
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