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Synthesis of azo-linked covalent organic polymers for pipette tip solid-phase extraction of sedative residues from animal tissues samples

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Abstract

Azo-linked covalent organic polymers (ACOPs) were synthesized by a simple azo reaction, with 2,2ʹ-bis(trifluoromethyl)benzidine and 1,3,5-trihydroxybenzene as the monomers. The preparation process was mild, green, and environmental-friendly, avoiding the use of high temperature, metal catalysis, and harmful organic reagent. The obtained ACOPs were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, powder X-ray diffraction, and Brunauer–Emmett–Teller. With the prepared ACOPs as adsorbent, a method of pipette tip solid-phase extraction–liquid chromatography–tandem mass spectrometry detection (PTSPE–LC–MS/MS) was proposed for the analysis of target sedatives in animal tissues. Furthermore, the parameters for the extraction of five sedatives, including the amount of adsorbent, pH value, ion strength, elution solvent and volume, were investigated. Under the optimized conditions, the linear dynamic range was found from 0.1 to 10.0 μg kg−1, and the limits of detection were ranged from 0.02 to 0.1 μg kg−1. The method was assessed by the analysis of target sedatives in animal tissues, and the recoveries for the spiked pork muscle and pork liver samples were 84–102% and 83–101%, respectively. The results show that the developed method of PTSPE–LC–MS/MS with ACOPs as adsorbent is efficient for the analysis of trace sedatives in animal tissues.

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References

  1. N.P. Wu, F.G. Ban, L. Peng, H.X. Zhou, Z.T. Liu, H.W. Liu, J. Chin. Mass Spectrom. Soc. 33, 94–98 (2012)

    CAS  Google Scholar 

  2. L.L. Cheng, Y.J. Zhang, J.Z. Shen, C.M. Wu, S.X. Zhang, Chromatographia 71, 155–158 (2010)

    Article  CAS  Google Scholar 

  3. L. Sun, L. Zhang, Q. Xu, S.H. Wang, X. Wang, Chin. J. Chromatogr. 28, 38–42 (2010)

    Article  CAS  Google Scholar 

  4. L.J. Yan, J. Zhang, C.S. Pan, L.Y. Lin, X.Y. Zhang, H.Q. Shen, Chin. J. Anal. Chem. 41, 31–35 (2013)

    Article  CAS  Google Scholar 

  5. L.P. Wang, H.X. Zhao, Y.M. Qiu, Z.Q. Zhou, J. Chromatogr. A 1136(1), 99–105 (2006)

    Article  CAS  PubMed  Google Scholar 

  6. G. Zhang, A.V. Jr Terry, M.G. Bartlett, J. Chromatogr. B 854(1–2), 68–76 (2007)

    Article  CAS  Google Scholar 

  7. L.Q. Zhang, P.G. Wu, Q. Jin, Y.M. Zhang, X.F. Wang, R. Ren, Chin. J. Health Lab. Technol. 23, 1634–1648 (2013)

    CAS  Google Scholar 

  8. GB 31650–2019 National food safety standard maximum residue limits of veterinary drugs in food.

  9. S.A. Meenagh, J.D.G. McEvoy, C.T. Elliott, Anal. Chim. Acta 462, 149–156 (2002)

    Article  CAS  Google Scholar 

  10. J. Cooper, P. Delahaut, T.L. Fodey, C.T. Elliott, Analyst 129, 169–174 (2004)

    Article  CAS  PubMed  Google Scholar 

  11. V. Cerkvenik-Flajs, Anal. Chim. Acta 586, 374–382 (2007)

    Article  CAS  PubMed  Google Scholar 

  12. L. Zhang, P. Wu, Q. Jin, H. Ye, X. Huang, S. Liu, Food Anal. Methods 10, 354–362 (2017)

    Article  Google Scholar 

  13. Y. Aoki, H. Hakamata, Y. Igarashi, K. Uchida, H. Kobayashi, N. Hirayama, A. Kotani, F. Kusu, J. Chromatogr. B 877, 166–172 (2009)

    Article  CAS  Google Scholar 

  14. L. Zhang, P. Wu, Q. Jin, Z. Hu, J. Wang, J. Chromatogr. B 1072, 305–314 (2018)

    Article  CAS  Google Scholar 

  15. J. Zhang, B. Shao, J. Yin, Y. Wu, H. Duan, J. Chromatogr. B 877, 1915–1922 (2009)

    Article  CAS  Google Scholar 

  16. K. Mitrowska, A. Posyniak, J. Zmudzki, Anal. Chim. Acta 637, 185–192 (2009)

    Article  CAS  PubMed  Google Scholar 

  17. Y. Ning, Y. Ye, W. Liao, Y. Xu, W. Wang, A. Wang, Food Chem. 397, 133831 (2022)

    Article  CAS  PubMed  Google Scholar 

  18. H. Sun, J. Feng, J. Feng, M. Sun, Y. Feng, M. Sun, Food Chem. 395, 133633 (2022)

    Article  CAS  PubMed  Google Scholar 

  19. R. Sun, F. Lu, C. Yu, Y. Yang, L. Qiao, A. Liu, J. Chromatogr. A 1673, 463101 (2022)

    Article  CAS  PubMed  Google Scholar 

  20. J. Yu, S. Di, H. Yu, T. Ning, H. Yang, S. Zhu, J. Chromatogr. A 1637, 461822 (2021)

    Article  CAS  PubMed  Google Scholar 

  21. Y. Yuan, S. Liang, H. Yan, Z. Ma, Y. Liu, J. Chromatogr. A 1408, 49–55 (2015)

    Article  CAS  PubMed  Google Scholar 

  22. T. Ben, Y. Li, L. Zhu, D. Zhang, D. Cao, Z. Xiang, X. Yao, S. Qiu, Energy Environ. Sci. 5(8), 8370–8376 (2012)

    Article  CAS  Google Scholar 

  23. S. Lin, C.S. Diercks, Y.B. Zhang, N. Kornienko, E.M. Nichols, Y. Zhao, A.R. Paris, D. Kim, P. Yang, O.M. Yaghi, C.J. Chang, Science 349(6253), 1208–1213 (2015)

    Article  CAS  PubMed  Google Scholar 

  24. G. Ji, Z. Yang, H. Zhang, Y. Zhao, B. Yu, Z. Ma, Z. Liu, Angew. Chem. Int. Ed. 55(33), 9685–9689 (2016)

    Article  CAS  Google Scholar 

  25. G. Ji, Z. Yang, H. Zhang, Y. Zhao, B. Yu, Z. Ma, Z. Liu, Angew. Chem. 128, 9837–9841 (2016)

    Article  Google Scholar 

  26. D. Li, M. He, B. Chen, B. Hu, J. Chromatogr. A 1601, 1–8 (2019)

    Article  CAS  PubMed  Google Scholar 

  27. Y. Yamini, M. Faraji, J. Pharm. Anal. 4(4), 279–285 (2014)

    Article  PubMed  PubMed Central  Google Scholar 

  28. S. Song, X. Shi, R. Li, Z. Lin, A. Wu, D. Zhang, Process. Biochem. 43, 1209–1214 (2008)

    Article  CAS  Google Scholar 

  29. G. Zhang, J.A.V. Terry, M.G. Bartlett, J. Chromatogr. B 854, 68–76 (2007)

    Article  CAS  Google Scholar 

  30. H.R. Sobhi, Y. Yamini, R. Haji Hosseini Baghdad Abadi, J. Pharm. Biomed. Anal. 45, 769–774 (2007)

    Article  CAS  PubMed  Google Scholar 

  31. C. Li, W.G. Huang Pu, Y. Ting, Y.L. Wu, Chin. J. Anal. Chem. 7, 1015–1018 (2010)

    Google Scholar 

Download references

Funding

This work was supported by the fund from Training Program for Academic and Technical Leaders of Major Disciplines in Jiangxi Province, China (20213BCJ22008), Basic research and Talent training Program of Jiangxi Academy of Agricultural Sciences (JXSNKYJCRC 202201), and the National quality and safety risk assessment of livestock and poultry products in 2022 (GJFP20220301).

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Authors and Affiliations

  1. Key Laboratory for Quality and Safety Control of Poultry Products, Ministry of Agriculture and Rural Affairs of the People’s Republic of China, Agricultural Product Quality Safety and Standards Institute, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China

    Jian Jun Xiang, Li Juan Yuan, Qie Gen Liao, Da Wen Zhang & Lin Guang Luo

Authors
  1. Jian Jun Xiang
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  2. Li Juan Yuan
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  3. Qie Gen Liao
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  4. Da Wen Zhang
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Correspondence to Qie Gen Liao.

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Xiang, J.J., Yuan, L.J., Liao, Q.G. et al. Synthesis of azo-linked covalent organic polymers for pipette tip solid-phase extraction of sedative residues from animal tissues samples. ANAL. SCI. 39, 1939–1946 (2023). https://doi.org/10.1007/s44211-023-00406-5

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  • DOI: https://doi.org/10.1007/s44211-023-00406-5

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