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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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Review Article

A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease

Author(s): Qiong Xiang, Xiao-Lin Liu, Jia-Jia Chen, Liang Yang, Li-Ni Liu, Jing Deng, Jia-Sheng Tao and Xian-Hui Li*

Volume 30, Issue 11, 2023

Published on: 16 November, 2023

Page: [891 - 899] Pages: 9

DOI: 10.2174/0109298665269246231023104904

Price: $65

Abstract

Gap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous system-related diseases and treatment are reviewed.

Keywords: Gap junction, connexin, genetic diseases, nervous system, apoptosis, cell proliferation, carcinogenesis.

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