Skip to main content

Advertisement

SpringerLink
Log in

Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis

  • Original Paper
  • Published:
Analytical Sciences Aims and scope Submit manuscript

Abstract

A new automated, generic analytical approach for determining the clinical disinfectant o-phthalaldehyde (OPA) is reported in this study. The proposed sequential injection analysis (SIA) is based on the online reaction of the OPA with glycine/N-acetylcysteine (NAC) in a neutral medium (pH = 7.0) to form a highly fluorescent isoindole derivative. All critical flow and reaction variables were investigated, while validation was carried out in the linearity detection range (0.0075–0.02%). As a result, excellent linearity (R2 > 0.99) and precision (1.5–2.4% for repeatability and 0.7–2.2% for reproducibility) were achieved for the reference OPA solutions. Furthermore, reasonable concentration verification of OPA disinfection (0.2–0.6%) in healthcare institutes can be achieved using the developed fluorescent SIA due to its good sensitivity (0.111 V/%) and precision (1.0–2.3% for intermediate precision) around the minimum effective concentration (MEC) of 0.3% for Cidex-OPA disinfectant.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. W.A. Rutala, D.J. Weber, Am. J. Infect. Control. 41, S2 (2013). https://doi.org/10.1016/j.ajic.2012.11.005

    Article  PubMed  Google Scholar 

  2. M.S. Favero, W.W. Bond, Disinfection, sterilization, and preservation (Lippincott Williams & Wilkins, Philadelphia, 2001), pp.881–918

    Google Scholar 

  3. L. Carlomagno, V.D. Huebner, H.R. Matthews, Anal. Biochem. 149, 344 (1985). https://doi.org/10.1016/0003-2697(85)90580-9

    Article  CAS  PubMed  Google Scholar 

  4. G. Blundell, W.G. Brydon, Clin. Chim. Acta 170, 79 (1987). https://doi.org/10.1016/0009-8981(87)90385-8

    Article  CAS  PubMed  Google Scholar 

  5. S.E. Walsh, J.-Y. Maillard, A.D. Russell, J. Appl. Microbiol. 86, 1039 (1999). https://doi.org/10.1046/j.1365-2672.1999.00791.x

    Article  CAS  PubMed  Google Scholar 

  6. M.J. Alfa, D.L. Sitter, J. Hosp. Infect. 26, 15 (1994). https://doi.org/10.1016/0195-6701(94)90075-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. C.G. Roberts, H. Chan Myers, Abstracts in Environmental and General Applied Microbiology, Q-265, ASM 98th General Meeting, Atlanta, Georgia USA, 1998 May, pp. 464–465

  8. A.W. Gregory, G.B. Schaalje, J.D. Smart, R.A. Robison, Infect. Control Hosp. Epidemiol. 20, 324 (1999). https://doi.org/10.1086/501625

    Article  CAS  PubMed  Google Scholar 

  9. A. Ballantyne, B. Berman, J. Toxicol. Cutan. Ocul. Toxicol. 3, 251 (1984). https://doi.org/10.3109/15569528409036279

    Article  CAS  Google Scholar 

  10. A. Ballantyne, S.L. Jordan, J. Appl. Toxicol. 21, 131 (2001). https://doi.org/10.1002/jat.741

    Article  CAS  PubMed  Google Scholar 

  11. S.E. Walsh, J.Y. Maillard, A.D. Russell, A.C. Hann, J. Appl. Microbiol. 91, 80 (2001). https://doi.org/10.1046/j.1365-2672.2001.01341.x

    Article  CAS  PubMed  Google Scholar 

  12. S.L. Jordan, Gastroenterol. Nurs. 18, 142 (1995)

    Article  Google Scholar 

  13. D.L. Pisaniello, R.T. Gun, M.N. Tkaczuk, M. Nitshcke, J. Crea, Appl. Occup. Environ. Hyg. 12, 171 (1997). https://doi.org/10.1080/1047322X.1997.10389484

    Article  CAS  Google Scholar 

  14. B. Ballantyne, R.C. Myers, Vet. Human Toxicol. 43, 193 (2001)

    CAS  Google Scholar 

  15. R.P.D. Cooke, S.V. Goddard, A. Whymant-Morris, J. Sherwood, R. Chatterly, J. Hosp. Infect. 54, 226 (2003). https://doi.org/10.1016/s0195-6701(03)00040-9

    Article  CAS  PubMed  Google Scholar 

  16. Johns Hopkins Medicine USA, Reliability assured with CIDEX® solution test strips. https://www.hopkinsmedicine.org/hse/forms/cidexopa/TestStrip.pdf, Accessed 9 Sept 2015

  17. K. Bowden, F.A. El-Kaissi, R.J. Ranson, J. Chem. Soc. Perkin Trans. II 12, 2089 (1990). https://doi.org/10.1039/P29900002089

    Article  Google Scholar 

  18. G. Ogden, P. Foldi, LC-GC 5, 28 (1987)

    CAS  Google Scholar 

  19. V. Concha-Herrera, J.R. Torres-Lapasi, M.C. Garca-Alvarez-Coque, J. Liq. Chromatogr. Relat. Technol. 27, 1593 (2004). https://doi.org/10.1081/JLC-120034094

    Article  CAS  Google Scholar 

  20. M. Roth, Anal. Chem. 43, 880 (1971). https://doi.org/10.1021/ac60302a020

    Article  CAS  PubMed  Google Scholar 

  21. D. Shea, W.A. MacCrehan, Anal. Chem. 60, 1449 (1988). https://doi.org/10.1021/ac00165a020

    Article  CAS  Google Scholar 

  22. C. Bertrand-Harb, M.G. Nicolas, M. Dalgalarraondo, J.M. Chobert, Sci. Aliments 13, 577 (1993)

    CAS  Google Scholar 

  23. C. Vannecke, S. Bare´, M. Bloomfield, D.L. Massart, J. Pharm. Biomed. Anal. 18, 963 (1999). https://doi.org/10.1016/S0731-7085(98)00105-8

    Article  CAS  PubMed  Google Scholar 

  24. R.L.C. Chen, B.-C. Hsieh, J.-S. Lin, T.-J. Cheng, Biosensors 13(4), 485 (2023). https://doi.org/10.3390/bios13040485

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. J. Ruzicka, E.H. Hansen, ACA 78, 145 (1975). https://doi.org/10.1016/S0003-2670(01)84761-9

    Article  CAS  Google Scholar 

  26. J. Ruzicka, G.D. Marshall, Anal. Chim. Acta 237, 329 (1990). https://doi.org/10.1016/S0003-2670(00)83937-9

    Article  CAS  Google Scholar 

  27. J.F. van Staden, R.I. Stefan, Talanta 64–5, 1109 (2004). https://doi.org/10.1016/j.talanta.2004.05.042

    Article  CAS  Google Scholar 

  28. R. Pe´rez-Olmos, J.C. Soto, N. Za´rate, A.N. Arau´jo, J.L.F.C. Lima, M.L.M.F.S. Saraiva, Food Chem. 90, 471 (2005). https://doi.org/10.1016/j.foodchem.2004.04.046

    Article  CAS  Google Scholar 

  29. C.E. Lenehan, N.W. Barnett, S.W. Lewis, Analyst 127, 997 (2002). https://doi.org/10.1039/B106791

    Article  CAS  PubMed  Google Scholar 

  30. A.M. Pimenta, M.C.B.S.M. Montenegro, A.N. Ara´ujo, J. Mart´ınez Calatayud, J. Pharm. Biomed. Anal. 40, 16 (2006). https://doi.org/10.1016/j.jpba.2005.10.006

    Article  CAS  PubMed  Google Scholar 

  31. N. Koizumi, R. Nishiyama, T. Masadome, Electrochem. 90–9, 097003 (2022). https://doi.org/10.5796/electrochemistry.22-00095

    Article  CAS  Google Scholar 

  32. G. N´ajera-Estebanjuan, E.G. Carrillo-Cedillob, M.P. Ca˜nizares-Mac´ıas, Anal. Methods 11, 2041 (2019). https://doi.org/10.1039/c9ay00228frsc.li/methods

    Article  Google Scholar 

  33. D.J. Cocovi-Solberg, M. Rosende, M. Michalec, M. Miro, Anal. Chem. 91, 1140 (2019). https://doi.org/10.1021/acs.analchem.8b04900

    Article  CAS  PubMed  Google Scholar 

  34. B. Kasetsoontorn, N. Choengchan, Anal. Chim. Acta 1097, 103 (2020). https://doi.org/10.1016/j.aca.2019.10.074

    Article  CAS  PubMed  Google Scholar 

  35. A. Baltima, H. Panagopoulou, A. Economou, C. Kokkinos, Anal. Chim. Acta 159, 338426 (2021). https://doi.org/10.1016/j.aca.2021.338426

    Article  CAS  Google Scholar 

  36. M. Fujiwara, Y. Ishida, N. Nimura, A. Toyama, T. Kinoshita, Anal. Biochem. 166, 72 (1987). https://doi.org/10.1016/0003-2697(87)90547-1

    Article  CAS  PubMed  Google Scholar 

  37. W.A. Rutala, D. J. Weber, the Healthcare Infection Control Practices Advisory Committee (HICPAC), Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008, Update: May 2019. https://www.cdc.gov/infectioncontrol/pdf/guidelines/disinfection-guidelines-H.pdf, Accessed 1 Aug 2023

  38. M.C. García Alvarez-Coque, M.J. Medina Hernández, R.M. Villanueva Camañas, C. Mongay Fernández, Anal. Biochem. 180(1), 172 (1989). https://doi.org/10.1016/0003-2697(89)90107-3

    Article  PubMed  Google Scholar 

  39. I. Molnar-Perl, I. Bozor, J. Chromatogr. A 798, 37 (1998). https://doi.org/10.1016/S0021-9673(97)01222-3

    Article  CAS  Google Scholar 

  40. P. Zuman, Chem. Rev. 104–7, 3217 (2004). https://doi.org/10.1021/cr0304424

    Article  CAS  Google Scholar 

  41. C. Moitessier, K. Kital, P.-E. Danjou, F. Cazier-Dennin, Talanta Open 2, 100014 (2020). https://doi.org/10.1016/j.talo.2020.100014

    Article  Google Scholar 

  42. S.M. Derayea, D.M. Nagy, K.M. Badr El-Din, T.Z. Attia, E. Samir, A.A. Mohamed, A.A. Hamad, RSC Adv. 12, 17607 (2022). https://doi.org/10.1039/d2ra02408j

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. M.G. Alvarez-Coque, M.M. Hernandez, R.V. Camanas, C.M. Fernandez, Anal. Biochem. 178–1, 1 (1989). https://doi.org/10.1016/0003-2697(89)90346-1

    Article  Google Scholar 

  44. D. Kutlán, P. Presits, I. Molnár-Perl, J. Chromatogr. A 949–1, 235 (2002). https://doi.org/10.1016/S0021-9673(01)01610-7

    Article  Google Scholar 

  45. J.F. Stobaugh, A.J. Repta, L.A. Sternson, K.W. Garren, Anal. Biochem. 135–1, 495 (1983). https://doi.org/10.1016/0003-2697(83)90718-2

    Article  Google Scholar 

  46. S.E. Douabale´, M. Dione, A. Coly, A. Tine, Talanta 60, 581 (2003). https://doi.org/10.1016/S0039-9140(03)00184-X

    Article  CAS  PubMed  Google Scholar 

  47. A. Tine, S.E. Douabalé, Reviews in fluorescence 2008 (Springer, New York, 2008), pp.195–218

    Google Scholar 

  48. W.A. Jacobs, J. Chromatogr. A 392, 435 (1987). https://doi.org/10.1016/S0021-9673(01)94288-8

    Article  CAS  Google Scholar 

  49. W.A. Jacobs, M.W. Leburg, E.J. Madaj, Anal. Biochem. 156–2, 334 (1986). https://doi.org/10.1016/0003-2697(86)90262-9

    Article  Google Scholar 

  50. E. Trepman, R.F. Chen, Arch. Biochem. 204–2, 524 (1980). https://doi.org/10.1016/0003-9861(80)90064-8

    Article  Google Scholar 

  51. H. Nakamura, A. Matsumoto, Z. Tamura, Anal. Lett. 15–17, 1393 (1982). https://doi.org/10.1080/00032718208064437

    Article  Google Scholar 

  52. N. Ren, M. Jia, J. Wu, J. Shanghai Ocean Univ. 28–6, 994 (2019)

    Google Scholar 

  53. K.-H. Chang, R.L.C. Chen, B.-C. Hsieh, P.-C. Chen, H.-Y. Hsiao, C.-H. Nieh, T.-J. Cheng, Biosens. Bioelectron. 26–4, 1507 (2010). https://doi.org/10.1016/j.bios.2010.07.100

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank the Ministry of Science and Technology of Taiwan, for financially supporting this research under Contract Nos. MOST-107-2313-B-002-015 and MOST-105-2313-B-002-022.

Author information

Authors and Affiliations

  1. Department of Biomechatronics Engineering, College of Bio-Resources and Agriculture, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan

    Hung-Yu Chen, Richie L. C. Chen, Bo-Chuan Hsieh & Tzong-Jih Cheng

  2. Department of Biomedical Engineering, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan

    Tzong-Jih Cheng

Authors
  1. Hung-Yu Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richie L. C. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bo-Chuan Hsieh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tzong-Jih Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tzong-Jih Cheng.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, HY., Chen, R.L.C., Hsieh, BC. et al. Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis. ANAL. SCI. 39, 2007–2017 (2023). https://doi.org/10.1007/s44211-023-00415-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s44211-023-00415-4

Keywords

Search

Navigation