1887

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Volume 72, Issue 11

Streptomyces: a natural source of anti- agents Open Access

This article is part of the Candida collection.

Abstract

There is an urgent need to source new compounds that can combat the current threat of serious infection caused by spp. and contend with the problem of antimicrobial resistance.

A synthesis of the evidence available from the current literature is needed to identify promising antifungal chemotherapeutics.

To highlight anti- compounds derived from spp. (a well-known source of antimicrobial compounds) that could translate to potential candidates for future clinical practice.

A comprehensive review was conducted across three scientific literature databases spanning a 13-year period.

We identified 151 compounds with anti- activity. Amongst these, 40 were reported with very strong inhibitory activity, having minimum inhibitory concentrations (MICs) against spp. of <3.5 µg ml, 66 compounds were considered strong inhibitors and 45 compounds exhibited moderate inhibitory potential. From an analysis of the MICs, we deduced that the actinomycin-like compounds RSP01 and RSP02 were probably the most promising anti- compounds. Other antifungals of note included filipin-like compounds, which demonstrated superior inhibition to amphotericin B and activity against and , and bafilomycin derivatives, which had substantial inhibition against .

It is essential to recognize the limitations inherent in the quest for new antifungals, which encompass toxicity, effectiveness and constraints associated with limited data access. However, further investigation through in-depth study and emerging technologies is of paramount importance, given that there are still many more compounds to discover. This review highlights the importance of antifungal compounds derived from , which demonstrate robust inhibition, and, in many cases, low toxicity, making them promising candidates for the development of novel antifungal agents.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): actinomycetes , antifungal , biomolecules , Candida , secondary metabolites and Streptomyces
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-11-22
2024-04-28
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Streptomyces: a natural source of anti-Candida agents
J. Med. Microbiol. 72, 001777 (2023); https://doi.org/10.1099/jmm.0.001777
/content/journal/jmm/10.1099/jmm.0.001777
/content/journal/jmm/10.1099/jmm.0.001777
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