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The role of CD146 in renal disease: from experimental nephropathy to clinics

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Abstract

Vascular endothelial dysfunction is a major risk factor in the development of renal diseases. Recent studies pointed out a major interest for the inter-endothelial junction protein CD146, as its expression is modulated during renal injury. Indeed, some complex mechanisms involving this adhesion molecule and its multiple ligands are observed in a large number of renal diseases in fundamental or clinical research. The purpose of this review is to summarize the most recent literature on the role of CD146 in renal pathophysiology, from experimental nephropathy to clinical trials.

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Acknowledgements

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Funding

This work was supported by the French National Research Agency (ANR GalCAM-AKI grant to EG, MBC and CEC, ANR-22-CE14-0045), the French National Institute of Health and Medical Research (Inserm) and Sorbonne University. ER is a doctoral fellow of the French Ministry of National Education (“Ecole Doctorale de Physiologie and Physiopathologie,” ED 394). LB is a fellow of the SFAR (“Société Française d’Anesthésie et de Réanimation”).

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Authors and Affiliations

  1. FHU PROMICE AP-HP, Saint Louis and DMU Parabol, Critical Care Medicine and Burn Unit, AP-HP, Department of Anesthesiology, University Paris Cité, 75010, Paris, France

    Louis Boutin, Etienne Gayat & François Depret

  2. INSERM, UMR-942, MASCOT, Cardiovascular Markers in Stress Condition, University Paris Cité, 75010, Paris, France

    Louis Boutin, Etienne Gayat & François Depret

  3. INSERM, UMR-S1155, Bâtiment Recherche, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France

    Louis Boutin, Elena Roger & Christos E. Chadjichristos

  4. Faculty of Medicine, Sorbonne University, 75013, Paris, France

    Elena Roger & Christos E. Chadjichristos

  5. Aix-Marseille Univ, INSERM INRA, C2VN, Marseille, France

    Marcel Blot-Chabaud

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  1. Louis Boutin
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  2. Elena Roger
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  3. Etienne Gayat
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Conceptualization, LB, CEC; writing—original draft preparation, LB, ER, MBC, and CEC; writing—review and editing, LB, ER, EG, FD, MCB, and CEC; supervision, CEC; project administration, CEC; funding acquisition, CEC. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Christos E. Chadjichristos.

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Boutin, L., Roger, E., Gayat, E. et al. The role of CD146 in renal disease: from experimental nephropathy to clinics. J Mol Med 102, 11–21 (2024). https://doi.org/10.1007/s00109-023-02392-7

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