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Volatile anticancer drug determination by thermal desorption technique with polydimethylsiloxane-coated macroporous silica adsorbent in gas chromatography–mass spectrometry

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  • Frontiers of Separation Analysis
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Abstract

An analytical method for quantifying the volatile anticancer drugs ifosfamide (IF) and cyclophosphamide (CP) in air was developed on the basis of thermal desorption (TD)–gas chromatography–mass spectrometry. Polydimethylsiloxane-coated macroporous silica was used as the adsorbent. The extraction tube was prepared by packing 0.2 g of adsorbent particles into a glass tube. The extraction and desorption efficiencies of the proposed method were quantitatively investigated in this study. The limits of detection of the proposed method for IF and CP were 3.3 ng L−1 at an air sampling volume of 3.0 L (30 min). The sensitivity of the proposed method was compared with using a Tenax TA packed tube that is widely used as the extraction medium in TD analysis. Finally, detection of IF and CP that evaporated from aqueous standard solution was investigated.

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Acknowledgements

This work was financially supported by JSPS KAKENHI (Grant numbers: 21K06491 and 21K05110) and JGC-S Scholarship Foundation Grant for Young Researchers.

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Authors and Affiliations

  1. Department of Applied Chemistry, University of Yamanashi, 4-3-11 Takeda, Kofu, 400-8511, Japan

    Ikuo Ueta, Katsunori Sumiya & Yuki Ariizumi

  2. Shinwa Chemical Industries Ltd., 50-2 Kagekatsu, Fushimi, Kyoto, 612-8307, Japan

    Koji Fujimura

  3. Department of Pharmacy, University of Yamanashi Hospital, 1110 Shimokato, Chuo, 409-3898, Japan

    Ryosuke Kikuchi & Keishi Kawata

  4. Department of Applied Chemistry and Life Science, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku, Toyohashi, 441-8580, Japan

    Yoshihiro Saito

Authors
  1. Ikuo Ueta
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  2. Katsunori Sumiya
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  3. Koji Fujimura
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  4. Yuki Ariizumi
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  5. Ryosuke Kikuchi
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  6. Keishi Kawata
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  7. Yoshihiro Saito
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Correspondence to Ikuo Ueta.

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Ueta, I., Sumiya, K., Fujimura, K. et al. Volatile anticancer drug determination by thermal desorption technique with polydimethylsiloxane-coated macroporous silica adsorbent in gas chromatography–mass spectrometry. ANAL. SCI. 40, 3–8 (2024). https://doi.org/10.1007/s44211-023-00449-8

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  • DOI: https://doi.org/10.1007/s44211-023-00449-8

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