Recent Advancements in the Synthesis of α-fluoroalkylated Azine-derived Heterocycles through Direct Fluorination

Title:Recent Advancements in the Synthesis of α-fluoroalkylated Azine-derived Heterocycles through Direct Fluorination

Volume: 21

Author(s): Oksana Shavrina, Yuliya Rassukana and Petro Onysko*

Affiliation:

• Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademika Kukharya str., Kyiv 02660, Ukraine

Keywords: Alkylazines; Pyridines; Pyrimidines; Fluorination; Fluoromethyl; Difluoromethyl, N-F fluorinating agents; DAST

Abstract: The review highlights recent advancements in the synthesis of α-fluoro and α,α- difluoroalkylated azines, focusing on two main approaches. The first approach involves nucleophilic deoxofluorination, wherein α-hydroxy- or α-oxoalkylated azines are treated with diethylaminosulfur trifluoride or other S-F reagents to introduce fluorine atoms. The second approach employs direct electrophilic benzylic fluorination, whereby alkylazines undergo fluorination using N-F reagents. Both methods provide flexibility in designing and synthesizing fluoroalkylated heterocycles.

Cite this article as:

Shavrina Oksana, Rassukana Yuliya and Onysko Petro*, Recent Advancements in the Synthesis of α-fluoroalkylated Azine-derived Heterocycles through Direct Fluorination, Current Organic Synthesis 2024; 21 () . https://dx.doi.org/10.2174/0115701794271650231016094853