Abstract
Cerebral cavernous malformations (CCM) can mimic other lesions such as thrombosed aneurysms. Completely thrombosed aneurysms (CTA) are rare, especially in non-giant aneurysms. We report a case of a 40-year-old man with a presumed insular CCM. A surgery was performed and revealed a thrombotic distal middle cerebral artery (MCA) aneurysm. The treatment consisted in sac incision and partial debulking. We reviewed the cases of thrombotic non-giant CTA and lesions mimicking CCM in the literature. Complete radiologic analysis and differential diagnosis remain crucial. For non-giant CTA, there is no clear consensus on their management, but they could be managed conservatively.
Similar content being viewed by others
Data availability
All materials and data support our claims and comply with the field standards.
Code Availability
Not applicable.
Abbreviations
- CCM:
-
Cerebral cavernous malformations
- CT:
-
Computed tomography
- CTA:
-
Completely thrombosed aneurysms
- IGA:
-
Intracranial giant aneurysm
- MCA:
-
Middle cerebral artery
- MRI:
-
Magnetic Resonance Imaging
References
Rinne J, Hernesniemi J, Niskanen M, Vapalahti M. Analysis of 561 patients with 690 middle cerebral artery aneurysms: anatomic and clinical features as correlated to management outcome. Neurosurgery. 1996;38(1):2–11. https://doi.org/10.1097/00006123-199601000-00002.
Cho YD, Park JC, Kwon BJ, Hee Han M. Endovascular treatment of largely thrombosed saccular aneurysms: follow-up results in ten patients. Neuroradiology. 2010;52(8):751–8. https://doi.org/10.1007/s00234-009-0622-8.
Spallone A, Peresedov VV, Kandel EI. Spontaneous cure of ruptured intracranial arterial aneurysms. Surg Neurol. 1981;16(5):367–70. https://doi.org/10.1016/0090-3019(81)90281-0.
dos Santos ML, Spotti AR, dos Santos RM, Borges MA, Ferrari AF, Colli BO, Tognola WA. Giant intracranial aneurysms: morphology and clinical presentation. Neurosurg Rev. 2013;36(1):117–22. https://doi.org/10.1007/s10143-012-0407-0.
Ribeiro de Sousa D, Vallecilla C, Chodzynski K, Corredor Jerez R, Malaspinas O, Eker OF, Ouared R, Vanhamme L, Legrand A, Chopard B, Courbebaisse G, Zouaoui Boudjeltia K. Determination of a shear rate threshold for thrombus formation in intracranial aneurysms. J Neurointerv Surg. 2016;8(8):853–8. https://doi.org/10.1136/neurintsurg-2015-011737.
Vandenbulcke A, Messerer M, Starnoni D, Puccinelli F, Daniel RT, Cossu G. Complete spontaneous thrombosis in unruptured non-giant intracranial aneurysms: A case report and systematic review. Clin Neurol Neurosurg. 2021;200. https://doi.org/10.1016/j.clineuro.2020.106319.
Malikov A, Secen AE, Daglioglu E, Belen AD. A pediatric case of completely thrombosed giant cavernous carotid aneurysm with ipsilateral ICA occlusion mimicking an intra-axial cystic lesion: a case report and review of the literature. Childs Nerv Syst. 2022;38:1809–12. https://doi.org/10.1007/s00381-022-05481-z.
Nguyen HS, Doan N, Eckardt G, Gelsomino M, Shabani S, Brown WD, Mueller W, Pollock G. A completely thrombosed, nongiant middle cerebral artery aneurysm mimicking an intra-axial neoplasm. Surg Neurol Int. 2015;6:146. https://doi.org/10.4103/2152-7806.164696.
Spallone A. Giant, completely thrombosed intracranial aneurysm simulating tumor of the foramen magnum. Surg Neurol. 1982;18(5):372–6. https://doi.org/10.1016/0090-3019(82)90155-0.
Päsler D, Baldauf J, Runge U, Schroeder HW. Intrameatal thrombosed anterior inferior cerebellar artery aneurysm mimicking a vestibular schwannoma. J Neurosurg. 2011;114(4):1057–60. https://doi.org/10.3171/2010.9.JNS10491.
Lim DH, Jung S, Jung TY, Kim TS. An Unusual Case of a Thrombosed Giant Distal PICA Aneurysm Simulating a Large Cavernous Angioma. J Korean Neurosurg Soc. 2008;43(3):155–8. https://doi.org/10.3340/jkns.2008.43.3.155.
Trungu S, Bruzzaniti P, Forcato S, Cimatti M, Raco A. Completely thrombosed distal middle cerebral artery aneurysm mimicking a cavernous angioma: case report and review of the literature. World Neurosurg. 2017;103:955.e1-955.e4. https://doi.org/10.1016/j.wneu.2017.04.172.
Fifi JT, Komotar R, Meyers P, Khandji A, Tanji K, Connolly ES. Restricted diffusion in a thrombosed anterior cerebral artery aneurysm mimicking a dermoid cyst. J Neuroimaging. 2012;22(1):85–8. https://doi.org/10.1111/j.1552-6569.2010.00495.x.
Woo PY, Ko NM, Chan KY. Thrombosed large distal posterior inferior cerebellar artery aneurysm mimicking an infratentorial ependymoma. Case Rep Neurol Med. 2014;2014:435953. https://doi.org/10.1155/2014/435953.
Ibrahim HG, Muhammad SB, Yunusa GH, et al. ‘Thrombosed large middle cerebral artery aneurysm in an 18 year old man: a case report’, Int J Biomed Res. 2022. [Online]. Available: https://doi.org/10.31579/IJBR-2021/050
Lan ZG, Ma L, Duan J, You C. A fully thrombosed giant posterior inferior cerebellar aneurysm mimicking an intracranial tumour in a child. Br J Neurosurg. 2012;26(6):888–90. https://doi.org/10.3109/02688697.2012.690911.
Kim YJ, Jeun SS, Park JH. Thrombosed large middle cerebral artery aneurysm mimicking an intra-axial brain tumor: case report and review of literature. Brain Tumor Res Treat. 2015;3(1):39-43. https://doi.org/10.14791/btrt.2015.3.1.39.
Choi YS, Kim DW, Jang SJ, Kang SD. Recanalization of completely thrombosed non-giant saccular aneurysm mimicking as de novo aneurysm. J Korean Neurosurg Soc. 2010;48(4):354–6. https://doi.org/10.3340/jkns.2010.48.4.354.
Boukobza M, Dossier A, Laissy JP. Thrombosed Aneurysm of the Posterior Inferior Cerebellar Artery and Lateral Medullary Ischemia as the Initial Presentation of Polyarteritis Nodosa: Case Report and Literature Review. J Stroke Cerebrovasc Dis. 2018;27(8):e168–71. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.061.
Calviere L, Viguier A, Da Silva NA, Cognard C Jr, Larrue V. Unruptured intracranial aneurysm as a cause of cerebral ischemia. Clin Neurol Neurosurg. 2011;113(1):28–33. https://doi.org/10.1016/j.clineuro.2010.08.016.
Fomenko A, Kaufmann AM. Spontaneous Thrombosis of an Unruptured Saccular Aneurysm Causing MCA Infarction. Can J Neurol Sci. 2016;43(6):856–8. https://doi.org/10.1017/cjn.2016.282.
Guillon B, Daumas-Duport B, Delaroche O, Warin-Fresse K, Sévin M, Hérisson F, Auffray-Calvier E, Desal H. Cerebral ischemia complicating intracranial aneurysm: a warning sign of imminent rupture? AJNR Am J Neuroradiol. 2011;32(10):1862–5. https://doi.org/10.3174/ajnr.A2645.
Rothwell PM, Algra A, Chen Z, Diener HC, Norrving B, Mehta Z. Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials. Lancet. 2016;388(10042):365–75. https://doi.org/10.1016/S0140-6736(16)30468-8.
Kuroda H, Mochizuki T, Shimizu S, Kumabe T. Rupture of Thrombosed Cerebral Aneurysm During Antithrombotic Therapy for Ischemic Stroke: Case Report and Literature Review. World Neurosurg. 2019;126:468–71. https://doi.org/10.1016/j.wneu.2019.02.238.
Author information
Authors and Affiliations
Contributions
MSR and PF contributed to this study. Materials, data collection, and analyses were performed by the two authors. The original draft was written by MSR, and PF reviewed, edited, and commented on previous versions of the manuscript. All authors approved the final manuscript.
Corresponding author
Ethics declarations
Ethics Approval
This report is in accordance with all ethical guidelines.
Consent to Participate
Written informed consent was obtained from the patient for their participation on this case report and accompanying images.
Consent for Publication
Written informed consent was obtained from the patient for the publication of this case report and accompanying images.
Conflict of Interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Surgery.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Soler-Rico, M., Finet, P. Thrombosed MCA Aneurysm Mimicking an Insular Cavernous Angioma: A Case Report and Literature Review. SN Compr. Clin. Med. 5, 279 (2023). https://doi.org/10.1007/s42399-023-01615-9
Accepted:
Published:
DOI: https://doi.org/10.1007/s42399-023-01615-9