Thromb Haemost 2024; 124(02): 149-151
DOI: 10.1055/s-0043-1776900
Invited Editorial Focus

NOACs in Atrial Fibrillation Patients with Polypharmacy

Bernadette Corica
1   Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom
2   Department of Translational and Precision Medicine, Sapienza—University of Rome, Rome, Italy
,
1   Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom
2   Department of Translational and Precision Medicine, Sapienza—University of Rome, Rome, Italy
,
3   Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
4   Division of Subacute Care, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy
› Author Affiliations




Publication History

Received: 23 October 2023

Accepted: 24 October 2023

Article published online:
21 November 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr 2017; 17 (01) 230
  • 2 Delara M, Murray L, Jafari B. et al. Prevalence and factors associated with polypharmacy: a systematic review and meta-analysis. BMC Geriatr 2022; 22 (01) 601
  • 3 Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf 2014; 13 (01) 57-65
  • 4 Palmer K, Villani ER, Vetrano DL. et al; European Geriatric Medicine Society Pharmacology special interest group. Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis. Eur Geriatr Med 2019; 10 (01) 9-36
  • 5 Leelakanok N, Holcombe AL, Lund BC, Gu X, Schweizer ML. Association between polypharmacy and death: a systematic review and meta-analysis. J Am Pharm Assoc (2003) 2017; 57 (06) 729-738.e10
  • 6 Corazza GR, Formagnana P, Lenti MV. Bringing complexity into clinical practice: an internistic approach. Eur J Intern Med 2019; 61: 9-14
  • 7 Romiti GF, Proietti M, Bonini N. et al; GLORIA-AF Investigators. Clinical complexity domains, anticoagulation, and outcomes in patients with atrial fibrillation: a report from the GLORIA-AF registry phase II and III. Thromb Haemost 2022; 122 (12) 2030-2041
  • 8 Romiti GF, Proietti M, Vitolo M. et al; ESC-EHRA EORP-AF General Long-Term Registry Investigators. Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry. BMC Med 2022; 20 (01) 326
  • 9 Proietti M, Vitolo M, Harrison SL. et al; ESC-EHRA EORP-AF Long-Term General Registry Investigators. Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry. BMC Med 2021; 19 (01) 256
  • 10 Rochon PA, Petrovic M, Cherubini A. et al. Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens. Lancet Healthy Longev 2021; 2 (05) e290-e300
  • 11 Pasina L, Brucato AL, Falcone C. et al. Medication non-adherence among elderly patients newly discharged and receiving polypharmacy. Drugs Aging 2014; 31 (04) 283-289
  • 12 Gallagher C, Nyfort-Hansen K, Rowett D. et al. Polypharmacy and health outcomes in atrial fibrillation: a systematic review and meta-analysis. Open Heart 2020; 7 (01) e001257
  • 13 Gorog DA, Gue YX, Chao TF. et al. Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: executive summary of a European and Asia-Pacific Expert Consensus Paper. Thromb Haemost 2022; 122 (10) 1625-1652
  • 14 Eggebrecht L, Nagler M, Göbel S. et al. Relevance of polypharmacy for clinical outcome in patients receiving vitamin K antagonists. J Am Geriatr Soc 2019; 67 (03) 463-470
  • 15 Grymonprez M, Petrovic M, De Backer TL, Steurbaut S, Lahousse L, Haemost T. The impact of polypharmacy on the effectiveness and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Thromb Haemost 2024; 124 (02) 135-148
  • 16 Jaspers Focks J, Brouwer MA, Wojdyla DM. et al. Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial. BMJ 2016; 353: i2868
  • 17 Piccini JP, Hellkamp AS, Washam JB. et al. Polypharmacy and the efficacy and safety of rivaroxaban versus warfarin in the prevention of stroke in patients with nonvalvular atrial fibrillation. Circulation 2016; 133 (04) 352-360
  • 18 Zheng Y, Li S, Liu X, Lip GYH, Guo L, Zhu W. Effect of oral anticoagulants in atrial fibrillation patients with polypharmacy: a meta-analysis. Thromb Haemost 2023; (e-pub ahead of print) DOI: 10.1055/S-0043-1770724.
  • 19 Kim DH, Pawar A, Gagne JJ. et al. Frailty and clinical outcomes of direct oral anticoagulants versus warfarin in older adults with atrial fibrillation : a cohort study. Ann Intern Med 2021; 174 (09) 1214-1223
  • 20 Proietti M, Romiti GF, Vitolo M. et al; ESC-EHRA EORP-AF General Long-Term Registry Investigators. Epidemiology and impact of frailty in patients with atrial fibrillation in Europe. Age Ageing 2022; 51 (08) afac192
  • 21 Proietti M, Romiti GF, Raparelli V. et al. Frailty prevalence and impact on outcomes in patients with atrial fibrillation: a systematic review and meta-analysis of 1,187,000 patients. Ageing Res Rev 2022; 79: 101652
  • 22 Martínez-Montesinos L, Rivera-Caravaca JM, Agewall S. et al. Polypharmacy and adverse events in atrial fibrillation: main cause or reflection of multimorbidity?. Biomed Pharmacother 2023; 158: 114064
  • 23 Bonde AN, Staerk L, Lee CJY. et al. Outcomes among patients with atrial fibrillation and appropriate anticoagulation control. J Am Coll Cardiol 2018; 72 (12) 1357-1365
  • 24 Chao TF, Joung B, Takahashi Y. et al. 2021 Focused update consensus guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: executive summary. Thromb Haemost 2022; 122 (01) 20-47
  • 25 Krittayaphong R, Treewaree S, Wongtheptien W, Kaewkumdee P, Lip GYH. Clinical phenotype classification to predict risk and optimize the management of patients with atrial fibrillation using the Atrial fibrillation Better Care (ABC) pathway: a report from the COOL-AF registry. QJM 2023; hcad219