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Topical Delivery of Methoxsalen Co-loaded Curcumin Using Hybrid Nanocarrier-Based Polymeric Hydrogel for Synergistic Therapy in the Treatment of Psoriasis

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Abstract

Purpose

Psoriasis is a chronic autoimmune inflammatory cutaneous disorder, and single-drug therapy is inadequate for curing this disease. Dual-drug therapy with multi-target synergistic effects may be an alternative approach to eradicate psoriasis. This study reports the development of a lipid-polymer hybrid nanoparticle (LPHNP)-based polymeric hydrogel for topical delivery of methoxsalen (MS) and curcumin (CUR) for the management of psoriasis.

Methods

MS-CUR-LPHNPs were prepared using the emulsification solvent evaporation method and incorporated into a Carbopol-940-based polymeric hydrogel for topical application. The antipsoriatic efficacy of the hydrogel was evaluated in an imiquimod (IMQ)-induced psoriasis rat model.

Results

Methoxsalen-co-loaded curcumin lipid-polymer hybrid nanoparticles (MS-CUR-LPHNPs, 206.8 ± 3.2 nm) were successfully prepared with a narrow polydispersity index (PDI = 0.174), negative zeta potential (− 27.1 ± 6.09 mV), and entrapment efficiency of 84.90 ± 0.68%. The polymeric hydrogel showed all the desirable characteristics essential for topical application. The MS-CUR-LPHNP-based polymeric hydrogel achieved superior anti-psoriatic effects in the IMQ-induced psoriasis rat model because of the high dermal retention of dual drugs for an extended period compared to a standard marketed anti-psoriatic formulation.

Conclusion

Therefore, we concluded that the developed MS-CUR-LPHNPs (D6-HNPs) were novel, providing synergistic therapeutic efficacy and promising prospects for the management of psoriasis.

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Data Availability

Data available on request to the corresponding author.

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Acknowledgements

The authors are thankful and grateful to the Drug Delivery Research Laboratory (DDRL), Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India, for providing the platform to conduct and carry out this research work.

Funding

This work was financially supported by All India Council for Technical Education (AICTE)-PG Scholarship Scheme.

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Authors and Affiliations

  1. Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, 786004, India

    Taison Jamatia, Sanjoy Das & Malay K Das

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  1. Taison Jamatia
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Contributions

All authors have contributed equally and approved the final version of the manuscript as submitted. TJ: experimental works, data processing, interpretation of data, statistical analysis, and manuscript writing; SD: figure design, statistical analysis, and interpretation; MKD: conception of the study, conceived, designed, and contributed to the formal analysis of the study, and reviewed/edited the manuscript.

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Correspondence to Malay K Das.

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Ethics Approval

The Institutional Animal Ethical Committee (IAEC) (Regd. No.1576/GO/Re/S/11/CPCSEA Dated:30/10/2018) of Dibrugarh University, Dibrugarh, Assam, India, approved the experimental protocol with approval number IAEC/DU/209, dated:26/2/2022. All the animal experiments were conducted following the guidelines by the Institutional Animal Ethics Committee (IAEC) of Dibrugarh University, Dibrugarh, Assam, India (Approval No. IAEC/DU/209, Dated. 26/02/2022).

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Jamatia, T., Das, S. & Das, M.K. Topical Delivery of Methoxsalen Co-loaded Curcumin Using Hybrid Nanocarrier-Based Polymeric Hydrogel for Synergistic Therapy in the Treatment of Psoriasis. J Pharm Innov 18, 2305–2324 (2023). https://doi.org/10.1007/s12247-023-09794-7

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