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Incidence and risk factors of venous thromboembolism in kidney transplantation patients: a prospective cohort study

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Abstract

To investigate the incidence and explore the risk factors of venous thromboembolism (VTE) within 6 months after kidney transplantation. Total of 331 kidney transplant recipients were assessed by venous ultrasonography for VTE at 14 days, 1 month, 3 months, and 6 months post-transplantation. Cox forward regression were used to identify the independent risk factors of VTE. This study registration number is ChiCTR1900020567 and the date of registration was 2019/01/08. The cumulative incidence of VTE was 2.72% (9/331) within 6 months after transplant. 77.8% (7/9) of VTEs occurred in the first 3 months post-transplantation. 88.9% (1/9) of VTEs were asymptomatic, 66.7% (6/9) of VTEs were mural thromboses and in the right lower extremity. Central vena catheterization (HR = 6.94) and severe pulmonary disease (including pneumonia) (HR = 57.35) were the risk factors for VTE in kidney transplantation recipients. KT patients are the high risk population of VTE. Future interventions should be strengthen for KT patients to receive a minimum of 3-month of precautionary measures for VTE, including infection prevention, and strengthening thromboprophylaxis on the CVC or transplanted side of lower extremity.

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Acknowledgements

Thanks sincerely for the statistical consultation by the Changhui Du. Thank you for providing language help from the library of Sichuan University West China Hospital.

Funding

This study was granted by the Science and Technology Department of Sichuan Province (2019YFS0288), West China Nursing Discipline Development Special Fund Project, Sichuan University (HXHL20022 & HXHL21014).

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Authors and Affiliations

  1. West China School of Nursing, Sichuan University/Ward of Nephrology and Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

    Shangping Zhao, Xiaoying Shi, Qiling Tan & Bo Gu

  2. West China School of Nursing, Sichuan University, Chengdu, Sichuan, China

    Hong Chen

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  1. Shangping Zhao
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  2. Hong Chen
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XS and QT performed research and analyzed the data; HC provided vital expertise; SZ and BG designed the research and wrote the manuscript.

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Correspondence to Bo Gu.

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Zhao, S., Chen, H., Shi, X. et al. Incidence and risk factors of venous thromboembolism in kidney transplantation patients: a prospective cohort study. J Thromb Thrombolysis 57, 278–284 (2024). https://doi.org/10.1007/s11239-023-02911-w

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