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The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits

  • OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE SYSTEMS
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Abstract—Plant polyphenols are characterized by a wide range of biological activities, including antioxidant properties, and have a high geroprotective potential. The purpose of this work was to investigate the effect of the extract of rowan berries (Sorbus aucuparia L.) on the lifespan and stress resistance of Drosophila melanogaster with the identification of possible mechanisms of its biological activity. It has been established that an ethanol extract of S. aucuparia berries, the main components of which are rutin and cyanidin-3-rutinoside, has a pronounced antioxidant activity in vitro. At the same time, treatment with rowan berry extract increased the resistance of D. melanogaster males to starvation, but reduced resistance to hyperthermia. In females, the extract reduced resistance to oxidative stress but increased resistance to hyperthermia. The effects of rowan berry extract on longevity depended both on its concentration and on the sex of fruit flies. In response to treatment with rowan berry extract, D. melanogaster males and females showed slight differences in the background level of expression of cellular stress response genes, including heat shock genes (hsp27, hsp68, and hsp83), oxidative stress resistance genes (hif1, nrf2, and sod1), circadian rhythm genes (clk and per), and the longevity gene sirt1, which may explain the differences in the observed effects.

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ACKNOWLEDGMENTS

The evaluation of antioxidant activity was carried out using the equipment of the Molecular Biology Center for Collective Use of the Institute of Biology of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences (Institute of Biology, Federal Research Center, Komi Scientific Center, Ural Branch, Russian Academy of Sciences).

Flies were used in the work (http://www.ckp-rf.ru/usu/471927/) and mouse (http://www.ckp-rf.ru/usu/471933/) from the scientific collections of experimental animals of the Federal Research Center of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences.

Funding

The research was carried out within the framework of the state task of the Institute of Biochemistry of the Federal Research Center of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences on the topic Genetic and functional studies of the effects of geroprotective interventions on the model Drosophila melanogaster (No. 122040600022-1).

Author information

Authors and Affiliations

  1. Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, 167982, Syktyvkar, Russia

    E. Yu. Platonova, D. A. Golubev, N. V. Zemskaya, O. G. Shevchenko & A. A. Moskalev

  2. Pitirim Sorokin Syktyvkar State University, 167001, Syktyvkar, Russia

    E. Yu. Platonova & D. A. Golubev

  3. Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, 167000, Syktyvkar, Russia

    S. A. Patov & M. V. Shaposhnikov

Authors
  1. E. Yu. Platonova
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  2. D. A. Golubev
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  3. N. V. Zemskaya
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  4. O. G. Shevchenko
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  5. S. A. Patov
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  6. M. V. Shaposhnikov
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  7. A. A. Moskalev
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Corresponding author

Correspondence to A. A. Moskalev.

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COMPLIANCE WITH ETHICAL STANDARDS

All studies using mice were performed in vitro on tissues of intact laboratory animals, without using animals as experimental objects.

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Conflict of interests. The authors declare that they have no conflicts of interest.

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Abbreviations: AAPH, 2,2'-azobis(amidinopropane) dihydrochloride; ABTS, (2,2'-azino-bis-(3-ethylbenzthiozolin-6-sulfonic acid)); DPPH, (2,2-diphenyl-1-picrylhydrazyl); LPO, lipid peroxidation.

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Platonova, E.Y., Golubev, D.A., Zemskaya, N.V. et al. The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits. Mol Biol 57, 978–992 (2023). https://doi.org/10.1134/S0026893323060134

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  • DOI: https://doi.org/10.1134/S0026893323060134

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