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Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes

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Abstract

In all cells—from bacteria to humans—nucleotide excision repair (NER) is a highly conserved, versatile DNA repair pathway that is responsible for the removal of a wide variety of DNA helix-distorting lesions arising from both endogenous and exogenous sources. In many organisms including bacteria, fungi, animals, and plants, NER occurs through two sub-pathways: the global genome NER (GG-NER) pathway and the transcription-coupled NER (TC-NER) pathway. Although essential factors and basic steps involved in NER have been identified, mechanisms and stages of their assembly process are not well understood. In this review, we summarize recent literature about protein interaction networks that manifest during initial stages of bacterial NER pathway while highlighting some of the key functional studies.

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Authors and Affiliations

  1. Department of Botany, Sri Venkateswara College, University of Delhi, Benito Juarez Marg, Dhaula Kuan, New Delhi, 110 021, India

    Manoj Thakur

  2. Department of Biochemistry, Indian Institute of Science, Bengaluru, 560 012, India

    Kalappa Muniyappa

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  1. Manoj Thakur
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  2. Kalappa Muniyappa
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MT conceptualized the manuscript, performed the literature search and wrote the manuscript along with KM. MT made the figure. MT and KM have read and agreed to the published version of the manuscript.

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Correspondence to Manoj Thakur.

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The authors declare that the research was conducted in the absence of any financial relationships that could be construed as a potential conflict of interest.

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Corresponding editor: Sanjeev Galande

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Thakur, M., Muniyappa, K. Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes. J Biosci 48, 56 (2023). https://doi.org/10.1007/s12038-023-00378-8

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