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Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence

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Abstract

Alcohol dependence is a disorder with a high recurrence rate that leads to a considerable public health burden. The risk of relapse appears to be related to a complex interplay of multiple factors. Herein, we aimed to explore the potential neural predictors of relapse in Chinese male patients with alcohol dependence. This study enrolled 58 male patients with alcohol dependence who had undergone acute detoxification. General demographic information and clinical features were collected. Magnetic resonance imaging data were used to measure cortical thickness across 34 regions of the brain. Patients were followed up at six months, and 51 patients completed the follow-up visit. These patients were divided into a relapser and an abstainer group. A binary logistic regression analysis was performed to investigate the potential risk factors of relapse. Compared to abstainers, relapsers showed higher inattention and non-planning impulsivity on the 11th version of the Barratt Impulsive Scale. The cortical thicknesses of the inferior-parietal lobules were significantly higher in abstainers compared with those in relapsers. Furthermore, binary logistic regression analysis showed that the thickness of the inferior parietal lobule predicted relapse, and lower non-planning impulse was a protective factor against relapse. Relapsers show poorer impulse control than abstainers, and structural magnetic resonance imaging revealed a decreased thickness of the inferior parietal lobule in relapsers. Our results indicate the thickness of the inferior parietal lobule as a potential relapse predictor in male patients with alcohol dependence.

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Acknowledgments

The authors wish to thank all the participants and supporters of this research.

Funding

This work was supported by a grant from the Beijing Municipal Commission of Science and Technology (Z211100002921039), Beijing Municipal Administration of Hospitals Clinical Medicine Development of special funding support (XMLX201834), and the National Institutes of Health (AA021449). There was no additional external funding received for this study. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096, People’s Republic of China

    Kebing Yang, Ruonan Du, Qingyan Yang, Rongjiang Zhao, Fengmei Fan, Song Chen, Shuping Tan, Zhiren Wang, Ting Yu, Baopeng Tian & Yunlong Tan

  2. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06519, USA

    Xingguang Luo & Chiang-Shan R. Li

  3. Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06519, USA

    Thang M. Le & Chiang-Shan R. Li

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  1. Kebing Yang
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Yunlong Tan, Kebing Yang and Ruonan Du were responsible for study design, Qingyan Yang, Rongjiang Zhao, Ting Yu, Fengmei Fan and Zhiren Wang were responsible for statistical analysis and manuscript preparation, Song Chen, Xingguang Luo, Zhiren Wang, Shuping Tan, Thang M. Le and Baopeng Tian were responsible for recruiting the patients and the data curation. Kebing Yang and Chiang-Shan R. Li were involved in evolving the ideas and edit the manuscript. All authors have contributed to and have approved the final manuscript.

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Correspondence to Yunlong Tan.

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Yang, K., Du, R., Yang, Q. et al. Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence. Brain Imaging and Behavior (2023). https://doi.org/10.1007/s11682-023-00838-7

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