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Mixed-Ligand Complex [Cu4(bpy)4(PO4)2(CO3)(H2O)2]: Synthesis, Crystal Structure, and Biological Properties

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Abstract

The reactions in the Cu(OAc)2⋅H2O–phytic acid–2,2'-bipyridine (bpy) system in aqueous methanol solutions resulted in the formation of a molecular different-ligand tetranuclear complex [(Cu4(bpy)4(PO4)2(CO3)(H2O)2]⋅13H2O (I), the structure of which was established from the X-ray diffraction data (CCDC no. 2262998). The molecule of complex I contains four non-equivalent Cu2+ cations, coordinating each two phosphate anions (\({\text{PO}}_{4}^{{3 - }}\) remaining after the transformation of the phytate ring), four neutral bpy molecules, two water molecules, and one carbonate anion (\({\text{CO}}_{3}^{{2 - }}\)). The presence of a large number of solvate water molecules in the outer coordination sphere gives rise to a hydrogen-bonded framework involved in stabilization of the crystal packing. Study of the antimycobacterial activity of I against non-pathogenic Mycolicibacterium smegmatis strain revealed high biological efficacy.

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ACKNOWLEDGMENTS

X-ray diffraction studies, elemental analysis, and IR spectroscopy were performed using equipment of the Center for Collective Use of Physical Investigation Methods of the Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences.

Funding

This study was performed within the framework of the state assignment for the Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences in the field of scientific research, programs of the Russian Academy of Sciences, and state assignment for the Institute of Chemistry, Far-Eastern Branch, Russian Academy of Sciences FWFN(0205)-2022-0003.

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    K. A. Koshenskova, D. E. Baravikov, F. M. Dolgushin, I. L. Eremenko & I. A. Lutsenko

  2. Institute of Chemistry, Far-Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia

    N. V. Makarenko

  3. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

    O. B. Bekker

Authors
  1. K. A. Koshenskova
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  2. N. V. Makarenko
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  3. D. E. Baravikov
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  4. F. M. Dolgushin
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  5. O. B. Bekker
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  6. I. L. Eremenko
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  7. I. A. Lutsenko
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Correspondence to N. V. Makarenko or I. A. Lutsenko.

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Translated by Z. Svitanko

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Koshenskova, K.A., Makarenko, N.V., Baravikov, D.E. et al. Mixed-Ligand Complex [Cu4(bpy)4(PO4)2(CO3)(H2O)2]: Synthesis, Crystal Structure, and Biological Properties. Russ J Coord Chem 49, 792–799 (2023). https://doi.org/10.1134/S1070328423601073

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