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The Role of Ubiquitin–Proteasome System in the Biology of Stem Cells

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Abstract

Selective degradation of cellular proteins by the ubiquitin–proteasome system (UPS) is one of the key regulatory mechanisms in eukaryotic cells. A growing body of evidence indicates that UPS is involved in the regulation of fundamental processes in mammalian stem cells, including proliferation, differentiation, cell migration, aging, and programmed cell death, via proteolytic degradation of key transcription factors and cell signaling proteins and post-translational modification of target proteins with ubiquitin. Studying molecular mechanisms of proteostasis in stem cells is of great importance for the development of new therapeutic approaches aimed at the treatment of autoimmune and neurodegenerative diseases, cancer, and other socially significant pathologies. This review discusses current data on the UPS functions in stem cells.

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Abbreviations

CSC:

cancer stem cell

ESC:

embryonic stem cell

HSC:

hematopoietic stem cell

iPSC:

induced pluripotent stem cell

MHC:

major histocompatibility complex

MSC:

mesenchymal stem cell

NSC:

neural stem cell

PSC:

pluripotent stem cell

SC:

stem cell

UPS:

ubiquitin–proteasome system

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Funding

The work was supported by the Ministry of Science and Higher Education of the Russian Federation (agreement no. 075-15-2020-773).

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia

    Alexander V. Burov, Andrey A. Rodin, Vadim L. Karpov & Alexey V. Morozov

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  1. Alexander V. Burov
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  2. Andrey A. Rodin
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  3. Vadim L. Karpov
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  4. Alexey V. Morozov
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A.V.B. and A.A.R. wrote the article; A.V.M. and V.L.K. edited the text.

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Correspondence to Alexey V. Morozov.

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Burov, A.V., Rodin, A.A., Karpov, V.L. et al. The Role of Ubiquitin–Proteasome System in the Biology of Stem Cells. Biochemistry Moscow 88, 2043–2053 (2023). https://doi.org/10.1134/S0006297923120076

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  • DOI: https://doi.org/10.1134/S0006297923120076

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