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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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Review Article

Advances in Research on Protein Arginine Methyltransferase 2: Functions and Diseases

Author(s): Zhen-Qi Min, Ming-Jun Jiang, Xi-Lian Liu, Su-Peng Yuan, Ping-An Chen, Chu-Hao Wang, Ya-Jun Chen* and Xian-Peng Dai*

Volume 31, Issue 1, 2024

Published on: 28 December, 2023

Page: [25 - 42] Pages: 18

DOI: 10.2174/0109298665281395231211060535

Price: $65

Abstract

Protein arginine methylation stands as a prevalent post-translational modification process, exerting vital roles in cellular signal transduction, gene expression, and cell cycle regulation. Amidst the protein arginine methyltransferase (PRMT) family, PRMT2 stands as a less explored constituent. Nonetheless, its regulatory roles in transcriptional regulation, post-transcriptional modification, methylation activity regulation, immunoregulation, and developmental regulation have garnered attention. These capabilities enable PRMT2 to exert pivotal regulatory functions in certain malignancies, metabolic disorders, inflammatory diseases, and atherosclerosis. In this review, we highlight the structure and functions of PRMT2, emphasizing its association with diseases. We also discuss PRMT2 inhibitors and explore the potential for therapeutic targeting.

Keywords: PRMT2, epigenetic regulation, transcriptional regulation, malignancies, atherosclerosis, inflammation.

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Graphical Abstract

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